Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer

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Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.2000016
P932PMC publication ID5169358
P698PubMed publication ID27977688

P50authorWoodring E. WrightQ59693488
Jerry W ShayQ89873929
P2093author name stringNing Zhang
Tsung-Po Lai
Andrew T Ludlow
Ilgen Mender
Guido Stadler
Jaewon Min
Wanil Kim
Jerome D Robin
P2860cites workHypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activityQ53387220
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescenceQ63977008
CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemiaQ77583270
Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoterQ78654076
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Human telomerase and its regulationQ24533247
Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsQ24632506
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial ImmunityQ24669850
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Telomerase activity and telomere length in male germ cellsQ28085343
Comprehensive mapping of long-range interactions reveals folding principles of the human genomeQ28131819
Topological domains in mammalian genomes identified by analysis of chromatin interactionsQ28264221
Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping FactorQ28268499
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoterQ28293716
Exclusion of Exon 2 Is a Common mRNA Splice Variant of Primate Telomerase Reverse TranscriptasesQ28714820
TRF2 and lamin A/C interact to facilitate the functional organization of chromosome endsQ29147479
SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophyQ30009101
Telomere length regulates ISG15 expression in human cellsQ33588778
Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolutionQ33983454
Telomere reduction in human colorectal carcinoma and with ageingQ34037761
CST meets shelterin to keep telomeres in checkQ34137320
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive elementQ34234726
Alternative splicing regulation of telomerase: a new paradigm?Q34310398
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.Q34518938
BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cellsQ34559617
A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesisQ34592331
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.Q34918219
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeatsQ35348831
Telomere dysfunction causes alveolar stem cell failureQ35549158
Telomerase activation by genomic rearrangements in high-risk neuroblastomaQ35806960
Telomere and telomerase in stem cellsQ36758330
Telomeres and age-related disease: how telomere biology informs clinical paradigmsQ36904429
Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophyQ37013579
Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cellsQ37305023
Regulation of human telomerase splicing by RNA:RNA pairingQ37627827
Chromatin and epigenetic regulation of the telomerase reverse transcriptase geneQ37825834
Transcriptional outcome of telomere signallingQ38218964
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Q38874534
Regulation of Telomerase Alternative Splicing: A Target for ChemotherapyQ39170483
An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer ProgressionQ39222368
Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.Q39291071
Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell ProliferationQ39294110
Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumorsQ39432537
Rearrangement of upstream sequences of the hTERT gene during cellular immortalizationQ39813604
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start siteQ40185373
p53-dependent down-regulation of telomerase is mediated by p21waf1.Q40515208
Lack of replicative senescence in normal rodent gliaQ40831347
Telomere position effect in human cellsQ43642023
Telomerase activity in human germline and embryonic tissues and cellsQ49024139
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)e2000016
P577publication date2016-12-15
P1433published inPLOS BiologyQ1771695
P1476titleRegulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer
P478volume14

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Q61373776Why are there associations between telomere length and behaviour?

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