Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization

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Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.373647
P8608Fatcat IDrelease_gkz2jodmz5eqnbp2vrzzxnohai
P932PMC publication ID3438943
P698PubMed publication ID22822073

P50authorDavid Piwnica-WormsQ124025940
P2093author name stringYu Li
Linda J Pike
Jennifer Macdonald-Obermann
Corey Westfall
P2860cites workAn allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorQ24293598
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerizationQ24296900
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alphaQ24307630
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domainsQ24307661
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animalsQ24563431
Cell signaling by receptor tyrosine kinasesQ24598357
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factorQ24648517
Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptorsQ27640631
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorQ27664092
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor ReceptorQ27664452
A single ligand is sufficient to activate EGFR dimersQ27681167
Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor functionQ28678683
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancerQ28678776
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingQ33886341
Single-molecule imaging of EGFR signalling on the surface of living cellsQ33892648
Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formationQ34025360
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.Q34489094
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand bindingQ35639911
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imagingQ35657617
Investigation of the dimerization of proteins from the epidermal growth factor receptor family by single wavelength fluorescence cross-correlation spectroscopyQ35850949
Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating systemQ36423352
Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptorQ37134352
Functional selectivity of EGF family peptide growth factors: implications for cancerQ37149729
Ligand-induced ErbB receptor dimerizationQ37154122
Structure-based view of epidermal growth factor receptor regulationQ37197992
The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptorsQ38298693
Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulationQ38669920
Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signalingQ39616171
Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances InternalizationQ39645178
All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.Q39941394
Preformed oligomeric epidermal growth factor receptors undergo an ectodomain structure change during signalingQ40205920
Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysisQ40402524
Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growthQ41682622
The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF bindingQ43131495
Prolonged EGFR signaling by ERBB2-mediated sequestration at the plasma membraneQ46935318
[22] Iodine monochloride (ICI) iodination techniquesQ56519011
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activationQ68818445
Iodine monochloride (IC1) iodination techniquesQ71746491
P433issue37
P407language of work or nameEnglishQ1860
P304page(s)31116-31125
P577publication date2012-07-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleQuantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization
P478volume287