Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia

scientific article published on November 1, 1992

Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.176.5.1303
P953full work available at URLhttps://europepmc.org/articles/PMC2119434
https://europepmc.org/articles/PMC2119434?pdf=render
P932PMC publication ID2119434
P698PubMed publication ID1402676
P5875ResearchGate publication ID269862299

P50authorPeter AplanQ89272233
P2093author name stringI. R. Kirsch
S. C. Raimondi
P2860cites workA new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsQ24299387
Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemiaQ24556540
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix proteinQ24556562
Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemiaQ24594559
The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motifQ24600549
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanomaQ24612665
The SCL gene is formed from a transcriptionally complex locusQ24633344
Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemiaQ24682636
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemiaQ28209032
Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemiasQ28253534
Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activityQ28266024
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcriptQ33845011
The chemistry and biology of left-handed Z-DNA.Q34055568
Site‐specific recombination in the immune system 1Q36831022
Structural and functional chimerism results from chromosomal translocation in lymphoid tumorsQ37512265
Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase modelQ37947573
Unusual DNA structuresQ39625578
Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumoursQ40819123
The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group studyQ44183966
New recurring chromosomal translocations in childhood acute lymphoblastic leukemiaQ70141044
A direct bone marrow chromosome technique for acute lymphoblastic leukemiaQ70394314
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectproto-oncogeneQ30555
patientQ181600
leukemiaQ29496
human chromosome 3Q668633
chromosomal translocationQ916504
lymphoblastic leukemiaQ18553852
P304page(s)1303-1310
P577publication date1992-11-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleDisruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia
P478volume176

Reverse relations

cites work (P2860)
Q31048792A single split-signal FISH probe set allows detection of TAL1 translocations as well as SIL-TAL1 fusion genes in a single test.
Q39148572Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia
Q89838430Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis
Q61455454An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression
Q35570942Causes of oncogenic chromosomal translocation
Q35756965Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.
Q36529795Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast
Q40963456Detection of chromosomal translocations in leukemia-lymphoma cells by polymerase chain reaction
Q41676689Factors involved in leukaemogenesis and haemopoiesis
Q41170258Genomic instability in 1p and human malignancies
Q28219251Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia
Q74801051Precursor T-lymphoblastic leukemia with a novel t(1;22)(p34;q13)
Q35712192Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia
Q38904484Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.
Q28143157Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type
Q47720703TAL1 expression does not occur in the majority of T-ALL blasts
Q58042312TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells
Q33263575Target DNA structure plays a critical role in RAG transposition
Q28247264The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses
Q33785164The stem cell leukaemia (SCL) gene: a critical regulator of haemopoietic and vascular development
Q36401517Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells.
Q38344708Transcription of Tal-1, A Putative Oncogene Playing an Important Role in Childhood T-All, Can be Shown in Normal Peripheral Blood Cells by a Highly Sensitive Rt-Pcr Assay
Q34479721Z-DNA-forming sequences generate large-scale deletions in mammalian cells

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