miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma.

scientific article

miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.3924
P932PMC publication ID4627343
P698PubMed publication ID25980496
P5875ResearchGate publication ID276851543

P50authorGlen M. BoyleQ37610927
Mitchell S. StarkQ54836800
Vanessa F BonazziQ55303023
Robert BallottiQ56451905
Christopher W. SchmidtQ73249629
Nicholas HaywardQ91316185
P2093author name stringPamela M Pollock
Jane M Palmer
Judith Symmons
Adrian C Herington
Catherine M Lanagan
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
A landscape of driver mutations in melanomaQ24603357
Exome sequencing identifies recurrent somatic RAC1 mutations in melanomaQ24607661
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequenceQ24652491
Elucidating distinct roles for NF1 in melanomagenesisQ27851952
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibitionQ27852017
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependenceQ27852894
Characterization of the Melanoma miRNAome by Deep SequencingQ28473165
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.Q30497690
A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viabilityQ31087541
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAsQ33742561
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesisQ33962607
A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growthQ34210051
miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 proteinQ34947386
In-depth characterization of microRNA transcriptome in melanomaQ34984013
MicroRNA profiling for the identification of cancers with unknown primary tissue-of-originQ35075757
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanomaQ35596369
A novel recurrent mutation in MITF predisposes to familial and sporadic melanomaQ35699278
In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA.Q36284875
Histology-specific microRNA alterations in melanomaQ36828567
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanomaQ37104104
Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras.Q37435516
MicroRNA regulation of melanoma progression.Q37972483
Loss of microRNA-205 expression is associated with melanoma progressionQ38325937
Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivoQ39158531
Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressorsQ39416723
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.Q39712781
miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanomaQ39884642
Characterization of microRNA expression levels and their biological correlates in human cancer cell linesQ40158414
Functional microRNA targets in protein coding sequencesQ42634002
Transcription factor/microRNA axis blocks melanoma invasion program by miR-211 targeting NUAK1.Q45241998
Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progressionQ46106828
Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor.Q53259136
MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis.Q55069393
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)17753-17763
P577publication date2015-07-01
P1433published inOncotargetQ1573155
P1476titlemiR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma
P478volume6

Reverse relations

cites work (P2860)
Q41763210Circulating microRNAs as Candidate Biomarkers for the Surveillance of Melanoma Patients
Q41862341Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells
Q40072818Discovery and characterization of the feline miRNAome
Q38704732Downregulation of miR-493 promoted melanoma proliferation by suppressing IRS4 expression
Q52584369Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells.
Q89967618Melanoma in the Eyes of Mechanobiology
Q47209993MiR-514a-3p inhibits cell proliferation and epithelial-mesenchymal transition by targeting EGFR in clear cell renal cell carcinoma
Q61417351MiRNAs in Malignant Melanoma
Q48293862MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway.
Q38700186MicroRNA-208b inhibits human osteosarcoma progression by targeting ROR2.
Q51091113MicroRNA-488-3p sensitizes malignant melanoma cells to cisplatin by targeting PRKDC.
Q38548766MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer
Q50062795MicroRNA-Directed Cancer Therapies: Implications in Melanoma Intervention.
Q90149506MicroRNAs as Mediators of Resistance Mechanisms to Small-Molecule Tyrosine Kinase Inhibitors in Solid Tumours
Q39101272MicroRNAs in melanoma development and resistance to target therapy
Q92618072Neurofibromin 1 expression is negatively correlated with malignancy and prognosis of epithelial ovarian cancer
Q59136531New insights in melanoma resistance to BRAF inhibitors: a role for microRNAs
Q36782461Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b
Q64269751Prognostic significance of deregulated microRNAs in uveal melanomas
Q64119763Role of miRNAs in Melanoma Metastasis
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Q41700266Small Non-coding RNA Abundance in Adrenocortical Carcinoma: A Footprint of a Rare Cancer.
Q37580297The "melanoma-enriched" microRNA miR-4731-5p acts as a tumour suppressor
Q35947544The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis
Q55004983The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis.
Q50019429Upregulation of MicroRNA-1246 Is Associated with BRAF Inhibitor Resistance in Melanoma Cells with Mutant BRAF.
Q49921953miR-204-5p and miR-211-5p Contribute to BRAF Inhibitor Resistance in Melanoma
Q47134272miR-514a-3p functions as a tumor suppressor in renal cell carcinoma.
Q37619788miR-7 reverses the resistance to BRAFi in melanoma by targeting EGFR/IGF-1R/CRAF and inhibiting the MAPK and PI3K/AKT signaling pathways
Q89697863miRNAs as Key Players in the Management of Cutaneous Melanoma
Q37362485microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB.
Q39393665scan_tcga tools for integrated epigenomic and transcriptomic analysis of tumor subgroups

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