ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.

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ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1003097100
P356DOI10.1186/1476-4598-11-36
P932PMC publication ID3442987
P698PubMed publication ID22640878
P5875ResearchGate publication ID225068687

P50authorJames D BrentonQ30506432
David A TumbarelloQ56544644
P2093author name stringJillian Temple
P2860cites workPeriostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motilityQ24306782
Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin IQ24312882
beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude miceQ24313409
Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosomeQ24314753
Integrin signalingQ28142010
Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancerQ28275904
Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagenQ28305358
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor betaQ28512724
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesisQ30441899
Structural and phylogenetic analyses of RGD-CAP/beta ig-h3, a fasciclin-like adhesion protein expressed in chick chondrocytesQ32085744
Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3.Q33910766
Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrinQ34150937
RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosisQ34188117
Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effectQ34191650
Interactions between cancer stem cells and their niche govern metastatic colonizationQ34239769
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathwayQ34314493
Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.Q34574099
TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-betaQ34656975
Chemotaxis of 3T3 and SV3T3 cells to fibronectin is mediated through the cell-attachment site in fibronectin and a fibronectin cell surface receptorQ36216864
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxelQ36289190
The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cellsQ36322653
Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.Q36411158
Modulating microtubule stability enhances the cytotoxic response of cancer cells to PaclitaxelQ36920871
Synergistic control of cell adhesion by integrins and syndecans.Q36986535
Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivityQ37004638
TGFBI deficiency predisposes mice to spontaneous tumor developmentQ37147623
Chromosomal instability determines taxane responseQ37208871
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatmenQ37277114
Signal co-operation between integrins and other receptor systemsQ37396456
Variants of the cell recognition site of fibronectin that retain attachment-promoting activityQ37569976
The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectinQ38288814
Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells.Q39697036
Cross-talk between integrins and oncogenes modulates chemosensitivityQ39892683
Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclonesQ39902244
Integrin cross-talk in endothelial cells is regulated by protein kinase A and protein phosphatase 1.Q39937527
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.Q40274571
Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancersQ40391221
Optimized expression and refolding of human keratoepithelin in BL21 (DE3).Q40522879
Induction and expression of betaig-h3 in pancreatic cancer cellsQ40697571
TGFBI expression is associated with a better response to chemotherapy in NSCLC.Q42736218
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cellsQ43722430
Purification and structural characterization of transforming growth factor beta induced protein (TGFBIp) from porcine and human corneas.Q45194844
Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathwayQ46417420
Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cellsQ46836540
De novo expression of the integrin alpha5beta1 regulates alphavbeta3-mediated adhesion and migration on fibrinogenQ47992377
Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells.Q52826677
Molecular properties of wild-type and mutant betaIG-H3 proteins.Q53673609
Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils.Q53932209
Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas.Q54519787
Expression and Function of β1 and αvβ3 Integrins in Ovarian CancerQ58025816
One-step purification of recombinant proteins with the 6xHis tag and Ni-NTA resinQ71190234
Expression of alpha(v)beta3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomasQ73227590
Secreted and cell surface genes expressed in benign and malignant colorectal tumorsQ74590931
Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitroQ77874135
BIGH3 is overexpressed in clear cell renal cell carcinomaQ80927686
BigH3 protein expression as a marker for breast cancerQ81121554
Beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromoleculesQ82360885
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
paclitaxelQ423762
P304page(s)36
P577publication date2012-05-28
P1433published inMolecular CancerQ15724585
P1476titleß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells
P478volume11