A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System

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A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System is …
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scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1269126C
P356DOI10.1371/JOURNAL.PONE.0169126
P932PMC publication ID5207518
P698PubMed publication ID28046023

P2093author name stringThanos D Halazonetis
Omar Zgheib
Remco P Crefcoeur
P2860cites workHistone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksQ29617463
Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA.Q33200674
The involvement of human RECQL4 in DNA double-strand break repairQ33539979
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cellsQ34044790
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand BreaksQ34531343
Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1Q34727801
RecQ helicases: multifunctional genome caretakersQ37573385
ATR: a master conductor of cellular responses to DNA replication stressQ37800265
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stressQ37885015
DNA replication stress as a hallmark of cancerQ38332707
DNA replication stress and cancer: cause or cure?Q38652528
DNA replication stress: from molecular mechanisms to human diseaseQ38707053
ATR-dependent phosphorylation of ATRIP in response to genotoxic stressQ40510496
ATRIP oligomerization is required for ATR-dependent checkpoint signalingQ42822679
Genome engineering using the CRISPR-Cas9 systemQ22122027
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityQ22254162
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EQ24301780
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationQ24523440
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial ImmunityQ24669850
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseQ26827954
Structure and conformational change of a replication protein A heterotrimer bound to ssDNAQ27674555
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51Q28207894
DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunitiesQ28272475
Focusing on foci: H2AX and the recruitment of DNA-damage response factorsQ28611373
ATR: an essential regulator of genome integrityQ29547883
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas systemQ29615782
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCas9Q16965677
CRISPR-Cas methodQ17310682
CRISPRQ412563
P304page(s)e0169126
P577publication date2017-01-03
P1433published inPLOS OneQ564954
P1476titleA Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System
P478volume12

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