Management of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approach

scientific article

Management of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approach is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3109/10428194.2011.568654
P932PMC publication ID3448554
P698PubMed publication ID21649549
P5875ResearchGate publication ID51198907

P50authorNeil E KayQ54295335
Clive S ZentQ57078355
P2860cites workGuidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelinesQ24616084
Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemiaQ24681296
TP53 mutation and survival in chronic lymphocytic leukemiaQ27851577
Cancer statistics, 2010Q27860525
Genomic aberrations and survival in chronic lymphocytic leukemiaQ28141442
Clinical staging of chronic lymphocytic leukemiaQ33337604
Autoimmune cytopenia does not predict poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphomaQ33349757
The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphomaQ33379107
Treatment of autoimmune cytopenia complicating progressive chronic lymphocytic leukemia/small lymphocytic lymphoma with rituximab, cyclophosphamide, vincristine, and prednisoneQ33388795
Autoimmune cytopenia in chronic lymphocytic leukemia: prevalence, clinical associations, and prognostic significanceQ33391574
Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximabQ33770207
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemiaQ33873337
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.Q33873343
Pentostatin and rituximab therapy for previously untreated patients with B-cell chronic lymphocytic leukemiaQ34056768
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trialQ34141305
CD5-positive chronic B-cell lymphoproliferative disorders: diagnosis and prognosis of a heterogeneous disease entity.Q34143223
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysisQ34282319
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemiaQ34402999
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemiaQ34617307
CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potentialQ35769292
Update on risk-stratified management for chronic lymphocytic leukemiaQ36634599
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drugQ36712736
Skin lesions in chronic lymphocytic leukemiaQ36814959
Genomic complexity identifies patients with aggressive chronic lymphocytic leukemiaQ36843780
De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experienceQ37028638
Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemiaQ37059754
Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioningQ37119402
Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphomaQ37163867
Treatment of elderly patients with chronic lymphocytic leukemiaQ37386705
Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemiaQ37621400
Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approachesQ37771673
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trialQ42994283
Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogeneticsQ43200452
Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemiaQ43598918
Veterans with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have a markedly increased rate of second malignancy, which is the most common cause of deathQ44560759
High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalitiesQ44613408
Comorbidity and functional status are independent in older cancer patientsQ44747457
Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features.Q45104774
CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphomaQ45115068
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemiaQ46112511
ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotypeQ46412983
Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic featuresQ46860354
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.Q46925495
Allogeneic CD3/CD28 cross-linked Th1 memory cells provide potent adjuvant effects for active immunotherapy of leukemia/lymphoma.Q51961547
Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT.Q53343426
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.Q53596463
A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.Q53650474
Interphase fluorescence in situ hybridization with an IGH probe is important in the evaluation of patients with a clinical diagnosis of chronic lymphocytic leukaemia.Q53668927
Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy.Q53962600
Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.Q54789536
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Q55036524
High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: A population-based Canadian cohortQ58436738
Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive diseaseQ71020959
p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemiasQ72626720
11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosisQ73260738
Chromosome anomalies detected by interphase fluorescence in situ hybridization: correlation with significant biological features of B-cell chronic lymphocytic leukaemiaQ73267761
Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. CLL Trialists' Collaborative GroupQ77788775
Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignanciesQ78773743
Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patientsQ81610592
A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable diseaseQ82081716
microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemiaQ82589392
Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p53 defectsQ83888306
CD5+ B-cell lymphoproliferative disorders: Beyond chronic lymphocytic leukemia and mantle cell lymphomaQ83981795
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
lymphocyteQ715347
chronic lymphocytic leukemiaQ1088156
P304page(s)1425-1434
P577publication date2011-06-08
P1433published inLeukemia & LymphomaQ6534493
P1476titleManagement of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approach
P478volume52

Reverse relations

cites work (P2860)
Q35569491Addition of granulocyte macrophage colony stimulating factor does not improve response to early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab
Q45792752An unusual presentation of a chronic lymphocytic leukemia patient with 17p deletion after reduced-intensity transplantation: Richter syndrome and concomitant graft-versus-host disease--case report.
Q39165643Attenuating homologous recombination stimulates an AID-induced antileukemic effect
Q36609259Chronic lymphocytic leukemia: inception to cure: are we there?
Q90143630Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment
Q38296806Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study
Q47359917Front-line treatment of patients with chronic lymphocytic leukemia: a systematic review and network meta-analysis
Q38003163High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature
Q36222910Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

Search more.