α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis

scientific article

α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.12-207969
P932PMC publication ID3448773
P698PubMed publication ID22767232

P2093author name stringJingchun Yang
Xiaolei Xu
P2860cites workTargeted disruption of nebulette protein expression alters cardiac myofibril assembly and functionQ24292243
Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathyQ24313460
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.Q24317266
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathyQ24337914
Early myocardial function affects endocardial cushion development in zebrafishQ24796758
Functional modulation of cardiac form through regionally confined cell shape changesQ27334821
Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible mannerQ28143885
Striated muscle cytoarchitecture: an intricate web of form and functionQ28216043
The vertebrate muscle Z-disc: sarcomere anchor for structure and signallingQ28261484
Zasp is required for the assembly of functional integrin adhesion sitesQ28263147
Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysisQ28268187
Zebrafish cypher is important for somite formation and heart developmentQ47073466
Tracking changes in Z-band organization during myofibrillogenesis with FRET imagingQ48887025
alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitroQ73807879
Cardiac myofibrillogenesis inside intact embryonic heartsQ28278810
Interaction of PKN with alpha-actininQ28303486
Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafishQ28475919
Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathyQ28587879
Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFMQ29028959
Effective targeted gene 'knockdown' in zebrafishQ29547445
The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructsQ29618810
Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assemblyQ30490809
Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2.Q30494192
Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heartQ33544983
Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.Q34083138
Immunostaining of dissected zebrafish embryonic heartQ34132681
The sarcomeric Z-disc: a nodal point in signalling and diseaseQ34485166
Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6.Q34753546
Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structuresQ35621909
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function.Q35672020
Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heartQ35758199
α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.Q35913031
Mechanics and function in heart morphogenesisQ36097892
α-actinin is required for the proper assembly of Z-disk/focal-adhesion-like structures and for efficient locomotion in Caenorhabditis elegansQ36231028
From A to Z and back? Multicompartment proteins in the sarcomere.Q36335814
Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypesQ36531015
Myofibrillogenesis visualized in living embryonic cardiomyocytesQ36571158
Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunctionQ36809320
Sarcomeric proteins and inherited cardiomyopathies.Q37023249
Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expressionQ37070209
Alpha-actinin structure and regulationQ37167269
Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.Q37292925
Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanismsQ37300161
Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebratesQ37484621
Dynamics of Z-band based proteins in developing skeletal muscle cellsQ41437699
Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expressionQ41974233
Myofibrillogenesis in skeletal muscle cells in zebrafishQ42027499
Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bandsQ42575972
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesisQ43998282
Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration.Q44193728
Cardiac troponin T is essential in sarcomere assembly and cardiac contractilityQ46049216
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titinQ47073224
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectDanio rerioQ169444
P304page(s)4230-4242
P577publication date2012-07-05
P1433published inFASEB JournalQ520194
P1476titleα-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis
P478volume26

Reverse relations

cites work (P2860)
Q39881934Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish
Q30571404Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis
Q39306560Depletion of Kindlin-2 induces cardiac dysfunction in mice
Q21146705Exome sequencing identifies a mutation in the ACTN2 gene in a family with idiopathic ventricular fibrillation, left ventricular noncompaction, and sudden death
Q38796202Exon- and contraction-dependent functions of titin in sarcomere assembly.
Q26746405Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing
Q93160562Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
Q40768343Kindlin-2 interacts with α-actinin-2 and β1 integrin to maintain the integrity of the Z-disc in cardiac muscles
Q38806486LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.
Q41692598Modeling GATAD1-Associated Dilated Cardiomyopathy in Adult Zebrafish
Q37662636New and TALENted genome engineering toolbox
Q55188606Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation.
Q39676931Strategies for analyzing cardiac phenotypes in the zebrafish embryo
Q36299864Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish
Q36702121Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening
Q27024639Understanding cardiac sarcomere assembly with zebrafish genetics

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