Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum

scientific article

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2015.08.018
P932PMC publication ID4634621
P698PubMed publication ID26629546
P5875ResearchGate publication ID282507656

P2093author name stringGraham Devereux
Jennifer Robertson
Douglas Fraser-Pitt
Deborah O'Neil
Derry Mercer
Edward Devlin
P2860cites workChronic infection with Achromobacter xylosoxidans in cystic fibrosis patients; a retrospective case control studyQ59139143
Antibiotic resistance of bacteria in biofilmsQ28207706
Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equationsQ28389258
Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis.Q30606113
N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosaQ33576307
In-vitro activity of antimicrobial agents against Neisseria gonorrhoeae in BrusselsQ33656023
Outcome for patients colonised with Burkholderia cepacia in a Birmingham adult cystic fibrosis clinic and the end of an epidemicQ33775997
The changing microbial epidemiology in cystic fibrosisQ33825634
Cysteamine: an old drug with new potential.Q34328193
The chemistry and biological activities of N-acetylcysteineQ34341263
Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis.Q35536317
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutationQ35852856
A randomized controlled crossover trial with delayed-release cysteamine bitartrate in nephropathic cystinosis: effectiveness on white blood cell cystine levels and comparison of safetyQ36067863
Activities of moxifloxacin in combination with macrolides against clinical isolates of Mycobacterium abscessus and Mycobacterium massiliense.Q36086312
Patient-reported outcomes in cystic fibrosisQ36891536
Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosisQ37334924
Antibiotic treatment of CF lung disease: from bench to bedsideQ37887170
The expanding armamentarium of drugs to aid sputum clearance: how should they be used to optimize care?Q38249201
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort studyQ41082564
Pantetheinase activity and cysteamine content in cystinotic and normal fibroblasts and leukocytesQ41636148
Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputumQ42054384
Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis.Q51711090
Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients.Q52858669
P433issue10
P921main subjectsputumQ259346
cystic fibrosisQ178194
patientQ181600
emerging pathogenQ108429945
P304page(s)1507-1512
P577publication date2015-08-10
P1433published inEBioMedicineQ24912341
P1476titleCysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum
P478volume2

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cites work (P2860)
Q41889486A Breathe in Cystic Fibrosis Therapy: A New Therapeutic Endeavor for Cysteamine
Q61803810Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease
Q37110307An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis
Q49733315Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect
Q37744944Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation
Q54247894Cysteamine, an Endogenous Aminothiol, and Cystamine, the Disulfide Product of Oxidation, Increase Pseudomonas aeruginosa Sensitivity to Reactive Oxygen and Nitrogen Species and Potentiate Therapeutic Antibiotics against Bacterial Infection.
Q38755670Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation
Q38722712Metabolic interactions between cysteamine and epigallocatechin gallate
Q36213831N-Acetyl-l-Cysteine and Cysteamine as New Strategies against Mixed Biofilms of Nonencapsulated Streptococcus pneumoniae and Nontypeable Haemophilus influenzae
Q38937131Nano-based rescue of dysfunctional autophagy in chronic obstructive lung diseases
Q42650380Strategies for the etiological therapy of cystic fibrosis

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