Defining mycobacteria: Shared and specific genome features for different lifestyles

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Defining mycobacteria: Shared and specific genome features for different lifestyles is …
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scholarly articleQ13442814

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P356DOI10.1007/S12088-009-0006-0
P932PMC publication ID3450044
P698PubMed publication ID23100749
P5875ResearchGate publication ID232706285

P2093author name stringWei Li
Patrick J Brennan
Varalakshmi D Vissa
Rama Murthy Sakamuri
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Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphateQ33726863
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A new evolutionary scenario for the Mycobacterium tuberculosis complexQ24531514
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The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutolQ24603359
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Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wallQ24678269
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Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug developmentQ24681801
CDD: a Conserved Domain Database for protein classificationQ24795306
Genomic homogeneity between Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis belies their divergent growth ratesQ24801171
The genome of Mycobacterium leprae: a minimal mycobacterial gene set.Q24805934
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.Q25256563
UDP-galactopyranose mutase has a novel structure and mechanismQ27635026
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discoveryQ27648874
Genes required for mycobacterial growth defined by high density mutagenesisQ27976512
Cell envelope composition and organisation in the genus RhodococcusQ28138340
Mycolic acids: structure, biosynthesis and physiological functionsQ28289888
Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosyQ28365902
Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteriaQ28486208
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameQ28486209
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase IIQ28486328
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycinQ28486452
Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthaseQ28486488
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteriaQ28486491
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosisQ28486505
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesisQ28486527
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-IIQ28486575
p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosisQ28486582
Investigating the function of the putative mycolic acid methyltransferase UmaA: divergence between the Mycobacterium smegmatis and Mycobacterium tuberculosis proteinsQ28486588
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosisQ28486711
AccD6, a member of the Fas II locus, is a functional carboxyltransferase subunit of the acyl-coenzyme A carboxylase in Mycobacterium tuberculosisQ28486744
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferaseQ28486772
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl riboseQ28486790
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophagesQ28486798
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosisQ28486804
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acidQ28486806
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetaseQ28486834
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1Q28486871
The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesisQ28486880
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosisQ28486885
Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosisQ28486917
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residuesQ28486923
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosisQ28486928
Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosisQ28486930
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosisQ28486935
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnoseQ28486980
X-ray structure of putative acyl-ACP desaturase DesA2 from Mycobacterium tuberculosis H37RvQ28487024
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesisQ28487038
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosisQ28487062
Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesisQ28487105
The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase coQ28487115
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in miceQ28487125
Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens?Q28487130
A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosisQ28487134
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesisQ28487164
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasBQ28487213
Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosisQ28487218
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infectionQ34034065
Genomics and bacterial pathogenesis.Q34040055
The decaying genome of Mycobacterium lepraeQ34112681
Antigen discovery: a postgenomic approach to leprosy diagnosisQ34300893
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strainsQ34318969
Differentiating host-associated variants of Mycobacterium avium by PCR for detection of large sequence polymorphismsQ34431942
Global dissemination of the Mycobacterium tuberculosis W-Beijing family strainsQ34469664
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosisQ34480164
Genomic evidence for the retention of the essential mycobacterial cell wall in the otherwise defective Mycobacterium leprae.Q34516494
The PE multigene family: a 'molecular mantra' for mycobacteriaQ34612597
Comparing genomes within the species Mycobacterium tuberculosisQ35033207
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organismsQ35122617
Lipoarabinomannans: from structure to biosynthesisQ35135570
A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosisQ35163364
Phagosomes, fatty acids and tuberculosisQ35210031
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcerQ35608680
Association between Mycobacterium tuberculosis Beijing/W lineage strain infection and extrathoracic tuberculosis: Insights from epidemiologic and clinical characterization of the three principal genetic groups of M. tuberculosis clinical isolatesQ35690557
The yersiniae--a model genus to study the rapid evolution of bacterial pathogensQ35709112
Mycobacterium avium in the postgenomic era.Q35783445
A genomic view of sugar transport in Mycobacterium smegmatis and Mycobacterium tuberculosisQ35949975
Beijing/W genotype Mycobacterium tuberculosis and drug resistanceQ36029451
Mycobacterial infections caused by nontuberculous mycobacteriaQ36222926
The dimycocerosate ester polyketide virulence factors of mycobacteria.Q36237897
Genome trees and the nature of genome evolutionQ36253571
Use of protein antigens for early serological diagnosis of leprosyQ36313571
Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosisQ36477317
Predominance of a single genotype of Mycobacterium tuberculosis in countries of east AsiaQ36526614
The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guérin (BCG) vaccines: is there a link?Q36565187
Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosisQ36603027
Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transferQ36634364
Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG.Q36797966
Protein secretion systems in Mycobacteria.Q36804773
Clinical relevance of Mycobacterium tuberculosis plcD gene mutationsQ37282843
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosisQ28487225
Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5Q28487230
Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acidsQ28487265
Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosisQ28487294
Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesisQ28487304
Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complexQ28487371
Mutually dependent secretion of proteins required for mycobacterial virulence.Q28487400
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium lepraeQ28487429
Phosphatidylinositol is an essential phospholipid of mycobacteriaQ28487431
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferaseQ28487466
Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrierQ28487534
Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complexQ28487542
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulenceQ28487543
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viabilityQ28487566
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesisQ28487576
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteriaQ28487603
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteriaQ28501849
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium speciesQ28501856
Genetic requirements for mycobacterial survival during infectionQ29547599
Report of the ad hoc committee for the re-evaluation of the species definition in bacteriologyQ29614356
CD-Search: protein domain annotations on the flyQ29615328
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisQ29617412
GenBankQ30324408
Tsukamurella paurometabola lipoglycan, a new lipoarabinomannan variant with pro-inflammatory activityQ30759401
Database resources of the National Center for Biotechnology Information.Q30825513
Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphureaQ31134174
The largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesisQ31147222
A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenesQ33217117
Gap, a mycobacterial specific integral membrane protein, is required for glycolipid transport to the cell surfaceQ33224239
Identification and characterization of the genes involved in glycosylation pathways of mycobacterial glycopeptidolipid biosynthesisQ33229425
Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regionsQ33263607
A phylogenomic analysis of the Actinomycetales mce operonsQ33275639
Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosisQ33279348
Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infectionQ33288220
Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strainsQ37415303
Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosidesQ37604908
Identification of a peptide synthetase involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis.Q38319825
Colonization of the salivary glands of Naucoris cimicoides by Mycobacterium ulcerans requires host plasmatocytes and a macrolide toxin, mycolactoneQ39217828
Phenolic glycolipid-1 (PGL-1) in Buruli ulcer lesions. First demonstration by immuno-histochemistry.Q39285680
A glycosyltransferase involved in biosynthesis of triglycosylated glycopeptidolipids in Mycobacterium smegmatis: impact on surface propertiesQ39362108
Glycopeptidolipid acetylation affects sliding motility and biofilm formation in Mycobacterium smegmatisQ39505047
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinumQ40170781
Aquatic snails, passive hosts of Mycobacterium ulceransQ40172563
Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium aviumQ40175764
PE_PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissuesQ40263062
Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environmentQ40591790
Reconstructing the ancestor of Mycobacterium leprae: the dynamics of gene loss and genome reduction.Q42107461
Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.Q42541926
Identification of a methyltransferase from Mycobacterium smegmatis involved in glycopeptidolipid synthesisQ42626084
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosisQ43001474
Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatisQ44170673
Genetic dissection of trehalose biosynthesis in Corynebacterium glutamicum: inactivation of trehalose production leads to impaired growth and an altered cell wall lipid compositionQ44509806
The phenolic mycoside of Mycobacterium ulcerans: structure and taxonomic implicationsQ44528262
Three pathways for trehalose metabolism in Corynebacterium glutamicum ATCC13032 and their significance in response to osmotic stressQ44531851
The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N‐terminal recognition region and a C‐terminal synthetic regionQ44594937
Trehalose is required for growth of Mycobacterium smegmatisQ44854772
Facile synthesis of arabinomannose penta- and decasaccharide fragments of the lipoarabinomannan of the equine pathogen, Rhodococcus equiQ44953815
Dimannosyldiacylglycerol serves as a lipid anchor precursor in the assembly of the membrane-associated lipomannan in Micrococcus luteusQ45106188
Dissection of phylogenetic relationships among 19 rapidly growing Mycobacterium species by 16S rRNA, hsp65, sodA, recA and rpoB gene sequencingQ45315916
A multigene approach to phylogenetic analysis using the genus Mycobacterium as a modelQ45315984
Regulation of the Mycobacterium tuberculosis PE/PPE genesQ47319382
Analysis of genetic polymorphisms affecting the four phospholipase C (plc) genes in Mycobacterium tuberculosis complex clinical isolates.Q47792819
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Type VII secretion--mycobacteria show the way.Q48689947
Temperature-sensitive mutants of the Mycobacterium plasmid pAL5000Q54669285
Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such asCorynebacterium glutamicumandMycobacterium tuberculosisQ58040456
Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with vaccine properties at least equal to those of M. bovis BQ58040570
Identification of Specific Proteins and Peptides in Mycobacterium leprae Suitable for the Selective Diagnosis of LeprosyQ58853025
A chemotaxonomic study of the lipoglycans of Rhodococcus rhodnii N445 (NCIMB 11279)Q71840673
Major structural features of the cell wall arabinogalactans of Mycobacterium, Rhodococcus, and Nocardia sppQ72692140
Characterisation of a lipomannan lipoglycan from the mycolic acid containing actinomycete Dietzia marisQ73504369
Identification of a lipoarabinomannan-like lipoglycan in Gordonia rubropertinctaQ73741819
Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS familyQ73827310
Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse modelQ80473523
Comparison of mammalian cell entry operons of mycobacteria: in silico analysis and expression profilingQ81340423
Structural elucidation of the predominant motifs of the major cell wall arabinogalactan antigens from the borderline species Tsukamurella paurometabolum and Mycobacterium fallaxQ81508891
P433issue1
P304page(s)11-47
P577publication date2009-02-05
P1433published inIndian Journal of MicrobiologyQ15749843
P1476titleDefining mycobacteria: Shared and specific genome features for different lifestyles
P478volume49

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cites work (P2860)
Q92921906A New Single Gene Differential Biomarker for Mycobacterium tuberculosis Complex and Non-tuberculosis Mycobacteria
Q33900542Comparative genomics of cell envelope components in mycobacteria
Q55514836GlnR-Mediated Regulation of Short-Chain Fatty Acid Assimilation in Mycobacterium smegmatis.
Q55366455Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features.
Q34468343Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis

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