Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein

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Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042800318
P356DOI10.1186/S12977-015-0218-9
P932PMC publication ID4636002
P698PubMed publication ID26545586
P5875ResearchGate publication ID283576744

P2093author name stringByung Soo Kim
Ji Chang You
Min-Jung Kim
Eun Soo Lee
Soo In Jang
Kyung Lee Yu
Seon Hee Kim
Jung Ae Park
P2860cites workInhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingersQ24605190
Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particlesQ24681117
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Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteinsQ28379468
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Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors.Q30366581
Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activityQ31107261
Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid proteinQ33436104
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transferQ33720677
Identification of HIV-1 inhibitors targeting the nucleocapsid protein.Q34269543
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replicationQ34364648
The HIV-1 nucleocapsid zinc finger protein as a target of antiretroviral therapyQ34373424
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.Q34418554
The determination of importance of sequences neighboring the Psi sequence in lentiviral vector transduction and packaging efficiencyQ34491104
Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1Q34965309
Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein.Q35166620
In vitro analysis of human immunodeficiency virus particle dissociation: gag proteolytic processing influences dissociation kineticsQ35184863
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivityQ35834904
Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitroQ35854311
Development of a cell-based assay probing the specific interaction between the human immunodeficiency virus type 1 nucleocapsid and psi RNA in vivoQ35857711
Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers.Q35990587
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanismQ36258296
A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virionsQ36523852
Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid proteinQ36791433
Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virusQ36804927
Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.Q36809360
Characterization of antiviral activity of benzamide derivative AH0109 against HIV-1 infectionQ37036503
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.Q37066805
HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitroQ37427179
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.Q37447762
Therapy for HIV: past, present, and futureQ37858308
Flexible nature and specific functions of the HIV-1 nucleocapsid proteinQ37901612
Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.Q38022377
Anti-HIV drug development: structural features and limitations of present day drugs and future challenges in the successful HIV/AIDS treatmentQ38054847
HIV Gag polyprotein: processing and early viral particle assemblyQ38069726
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunitsQ38989507
Sargassum fusiforme fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptaseQ39341026
Identification of the HIV-1 packaging RNA sequence (Ψ) as a major determinant for the translation inhibition conferred by the HIV-1 5' UTR.Q39429052
A time-of-drug addition approach to target identification of antiviral compoundsQ39531429
Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replicationQ39578721
Role of Vif in stability of the human immunodeficiency virus type 1 coreQ39597709
Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesisQ39880993
Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycleQ40405392
Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.Q40980778
Generation of the replication-competent human immunodeficiency virus type 1 which expresses a jellyfish green fluorescent proteinQ41116485
Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.Q41270026
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compoundsQ42289296
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitorsQ43891613
Cleavage of Gag precursor is required for early replication phase of HIV-1Q57178516
Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replicationQ77362262
Mechanistic studies of mini-TAR RNA/DNA annealing in the absence and presence of HIV-1 nucleocapsid proteinQ80234107
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesisQ81690042
P921main subjectviral nucleocapsidQ4384107
P304page(s)90
P577publication date2015-11-06
P1433published inRetrovirologyQ15793508
P1476titleIdentification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein
P478volume12

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cites work (P2860)
Q40560606Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus
Q36342362Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.
Q52595590Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production.

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