The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae

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The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.135.6.1789
P932PMC publication ID2133951
P698PubMed publication ID8991091
P5875ResearchGate publication ID277388151

P2093author name stringG S Payne
P K Tan
J P Howard
P2860cites workNucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiaeQ24555795
Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domainQ24556506
Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pitsQ24564624
In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesiclesQ24564687
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furinQ24568252
Transformation of intact yeast cells treated with alkali cationsQ24672708
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsQ27913878
The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiaeQ27929499
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutantQ27932509
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genesQ27934841
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformationQ67802007
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turnQ67802010
Clathrin: a role in the intracellular retention of a Golgi membrane proteinQ69538447
The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromoneQ69835296
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosisQ70332231
The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localizationQ72571291
AdaptinsQ75293949
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factorQ27935541
The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complexQ27936479
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine proteaseQ27939796
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeastQ28131609
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptorQ28254985
Receptors compete for adaptors found in plasma membrane coated pitsQ28283978
Interaction of tyrosine-based sorting signals with clathrin-associated proteinsQ28290076
Analysis and prediction of the different types of beta-turn in proteinsQ28292391
Targeting of membrane proteins to endosomes and lysosomesQ28612146
Production of single-stranded plasmid DNAQ29547328
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosisQ29617390
The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeastQ29620819
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiaeQ34056924
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptorsQ34196707
Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeastQ34436938
In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sortingQ35851542
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequenceQ36233082
Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.Q36235242
Ubiquitination of the yeast a-factor receptorQ36237205
Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiaeQ36531659
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signalsQ36531709
Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeastQ36534814
A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related proteinQ37378077
A novel endocytosis signal related to the KKXX ER-retrieval signalQ37697278
Enzymes required for yeast prohormone processingQ39644456
Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuoleQ40241598
Retention and retrieval in the endoplasmic reticulum and the Golgi apparatusQ40647410
Sorting of membrane proteins in the yeast secretory pathwayQ40734090
Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptorQ40817578
TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domainQ40872991
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.Q41229177
Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tailQ41690827
The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi networkQ41907333
Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functionsQ42679466
Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptorsQ42769697
Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosisQ44834985
A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pitsQ45839792
The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domainQ46258852
Dynamic retention of TGN membrane proteins in Saccharomyces cerevisiaeQ46349111
Assay of yeast mating reactionQ46855519
In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase.Q48266562
Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.Q52516857
P433issue6 Pt 2
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P1104number of pages12
P304page(s)1789-1800
P577publication date1996-12-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae
P478volume135

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cites work (P2860)
Q42961352A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo
Q47862859A function for monoubiquitination in the internalization of a G protein-coupled receptor
Q36255680A large PEST-like sequence directs the ubiquitination, endocytosis, and vacuolar degradation of the yeast a-factor receptor
Q29620135Actin Assembly and Endocytosis: From Yeast to Mammals
Q34667847Actin and endocytosis in budding yeast
Q27937214Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane
Q45271574Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains
Q53555987Aspergillus nidulans flippase DnfA is cargo of the endocytic collar and plays complementary roles in growth and phosphatidylserine asymmetry with another flippase, DnfB.
Q24313034Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module
Q34382206Cargo recognition in clathrin-mediated endocytosis
Q27934636Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae
Q43622198Coexistence and expression profiles of two alternative splice variants of the pheromone receptor gene pre‑1 in Neurospora crassa
Q37544873Design of Stable α-Helical Peptides and Thermostable Proteins in Biotechnology and Biomedicine
Q36608402Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates TGN to prevacuolar compartment transport and is regulated by phosphorylation
Q93039411Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis
Q35623173Dynamics of endosomal sorting
Q28256423EH: a novel protein-protein interaction domain potentially involved in intracellular sorting
Q50218239Effect of a Flexible Linker on Recombinant Expression of Cell-Penetrating Peptide Fusion Proteins and Their Translocation into Fungal Cells.
Q34237484Endocytosis and downregulation of G protein-coupled receptors
Q33533771Endocytosis: EH domains lend a hand
Q38609830Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.
Q28509479Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization
Q45080882Inhibition of Staphylococcus aureus gene expression and growth using antisense peptide nucleic acids
Q30175978Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.
Q24634104Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network
Q22010761Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Q32062433Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases
Q34201680Molecular requirements for the internalisation step of endocytosis: insights from yeast
Q34661258Monoubiquitin carries a novel internalization signal that is appended to activated receptors
Q43610822Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis
Q77136123Multiple sorting pathways between the late Golgi and the vacuole in yeast
Q29870853NPFXD-mediated endocytosis is required for polarity and function of a yeast cell wall stress sensor
Q22010462PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins
Q27932146Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis
Q41769960Prm1 Targeting to Contact Sites Enhances Fusion during Mating in Saccharomyces cerevisiae
Q57179714Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
Q28183439Pygopus residues required for its binding to Legless are critical for transcription and development
Q31971634Recognition specificity of individual EH domains of mammals and yeast
Q36342583Recycling of the yeast a-factor receptor
Q29619145Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins
Q37475303Requirements for recruitment of a G protein-coupled receptor to clathrin-coated pits in budding yeast
Q58558639Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane
Q37883980Secretory carrier membrane proteins.
Q27930516Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis
Q27934739Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.
Q27644086Structure of Sla1p homology domain 1 and interaction with the NPFxD endocytic internalization motif
Q37375063Targeted disruption of an EH-domain protein endocytic complex, Pan1-End3.
Q40243667The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors
Q27937052The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast
Q33957071The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization
Q44846212The internalization of yeast Ste6p follows an ordered series of events involving phosphorylation, ubiquitination, recognition and endocytosis
Q37973321The regulation of filamentous growth in yeast
Q35190873The role of ubiquitin in down-regulation and intracellular sorting of membrane proteins: insights from yeast
Q35036574The role of ubiquitylation in signaling by growth factors: implications to cancer
Q30168763The secretory carrier membrane protein family: structure and membrane topology
Q44301552The signal peptide NPFSD fused to ricin A chain enhances cell uptake and cytotoxicity in Candida albicans
Q47878504The single ENTH-domain protein of trypanosomes; endocytic functions and evolutionary relationship with epsin
Q24669945The yeast actin cytoskeleton: from cellular function to biochemical mechanism
Q43944987Ubiquitin-independent entry into the yeast recycling pathway
Q39033646Ubiquitination and the Regulation of Membrane Proteins
Q73538505Ubiquitination of the PEST-like endocytosis signal of the yeast a-factor receptor
Q34774715Versatile roles of k63-linked ubiquitin chains in trafficking
Q35613387Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD/Sla1p endocytic pathway.

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