Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution

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Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution is …
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scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90.3745M
P356DOI10.1073/PNAS.90.8.3745
P932PMC publication ID46378
P698PubMed publication ID8475124
P5875ResearchGate publication ID14724437

P2093author name stringF W Smith
J Feigon
P Schultze
J A Roe
R F Macaya
P2860cites workDNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNAQ24643021
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structuresQ27642123
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymeraseQ27860794
In vitro selection of RNA molecules that bind specific ligandsQ27861109
A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromoleculesQ29616473
Monovalent cation-induced structure of telomeric DNA: the G-quartet modelQ30459609
Hematin: unique effects of hemostasisQ33481903
SELEXION. Systematic evolution of ligands by exponential enrichment with integrated optimization by non-linear analysisQ34001832
Selection of single-stranded DNA molecules that bind and inhibit human thrombinQ34616171
1H NMR spectroscopy of DNAQ35234242
In vitro geneticsQ35342098
RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptaseQ37130872
Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T)Q37210778
Four-stranded nucleic acid structures 25 years later: from guanosine gels to telomer DNA.Q37803905
Multinuclear nuclear magnetic resonance studies of Na cation-stabilized complex formed by d(G-G-T-T-T-T-C-G-G) in solution. Implications for G-tetrad structuresQ38331888
Characterization by 1H NMR of glycosidic conformations in the tetramolecular complex formed by d(GGTTTTTGG).Q40506516
Hematin-derived anticoagulant. Generation in vitro and in vivoQ41814752
Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with anti glycosidic torsion angles in solutionQ41833077
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loopsQ41958822
Crystal structure of four-stranded Oxytricha telomeric DNAQ43751324
Quadruplex structure of Oxytricha telomeric DNA oligonucleotidesQ43784662
Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediatesQ44858268
A sodium-potassium switch in the formation of four-stranded G4-DNAQ59082353
Tetraplex formation of a guanine-containing nonameric DNA fragmentQ68598305
The inactivation of hemostatic factors by hematinQ70445522
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3745-3749
P577publication date1993-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution
P478volume90

Reverse relations

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Q38341829Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer
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Q30718304DNA aptamers derived from HIV-1 RNase H inhibitors are strong anti-integrase agents
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Q38308740Design, synthesis and properties of artificial nucleic acids from (R)-4-amino-butane-1,3-diol
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Q34545333Detection of cyclic diguanylate G-octaplex assembly and interaction with proteins
Q40967435Development and Optimization of a Thrombin Sandwich Aptamer Microarray
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Q38762964Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.
Q92205951Differences in firing efficiency, chromatin, and transcription underlie the developmental plasticity of the Arabidopsis DNA replication origins
Q38502054Direct detection of thrombin binding to 8-bromodeoxyguanosine-modified aptamer: effects of modification on affinity and kinetics
Q37277677Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
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Q27687856Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer
Q37327552Effect of linker structure on surface density of aptamer monolayers and their corresponding protein binding efficiency
Q37083367Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamer
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Q37294897Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
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Q88330843Fast-Folding Pathways of the Thrombin-Binding Aptamer G-Quadruplex Revealed by a Markov State Model
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Q38309057G quadruplex-based FRET probes with the thrombin-binding aptamer (TBA) sequence designed for the efficient fluorometric detection of the potassium ion.
Q66679479G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications
Q40724066G-Quadruplexes with Tetra(ethylene glycol)-Modified Deoxythymidines are Resistant to Nucleases and Inhibit HIV-1 Reverse Transcriptase.
Q38299950G-quadruplex induced stabilization by 2'-deoxy-2'-fluoro-D-arabinonucleic acids (2'F-ANA).
Q35147126G-quadruplex structures and their interaction diversity with ligands
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Q36424445Generation of Internal-Image Functional Aptamers of Okadaic Acid via Magnetic-Bead SELEX.
Q33991887Generation of an enriched pool of DNA aptamers for an HER2-overexpressing cell line selected by Cell SELEX.
Q31047047GnRH binding RNA and DNA Spiegelmers: a novel approach toward GnRH antagonism
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Q40400495High-affinity RNA ligands to human alpha-thrombin
Q27679511High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
Q52572512Homogeneous DNA sensing using enzyme-inhibiting DNA aptamers.
Q36959489Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics
Q38329552Human thrombin detection through a sandwich aptamer microarray: interaction analysis in solution and in solid phase
Q36841882Hybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNA
Q36684456Hydration and solution structure of nucleic acids
Q54239430Identification of G-quadruplex forming sequences in three manatee papillomaviruses.
Q38288235Identification of two novel arginine binding DNAs.
Q28484118Identification, characterization and application of a G-quadruplex structured DNA aptamer against cancer biomarker protein anterior gradient homolog 2
Q39556691Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends
Q34559605Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer
Q45742012In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?
Q37528801In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands
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Q38315674Insight into the molecular recognition of spermine by DNA quadruplexes from an NMR study of the association of spermine with the thrombin-binding aptamer
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Q38358445Multifunctional G-quadruplex aptamers and their application to protein detection
Q34628747Multiple types of logic gates based on a single G-quadruplex DNA strand
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Q40969318NMR solution structure of a parallel LNA quadruplex.
Q38013448NMR spectroscopy of G-quadruplexes
Q38339750NMR structure of the thrombin-binding DNA aptamer stabilized by Sr2+.
Q42918212Nanogap dielectric spectroscopy for aptamer-based protein detection
Q89634215New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures
Q33878021Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH-π interactions.
Q41000979Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae.
Q37014667Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases
Q55340827Novel isoguanine derivative of unlocked nucleic acid-Investigations of thermodynamics and biological potential of modified thrombin binding aptamer.
Q26825644Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing
Q47104247Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery.
Q37972851Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects.
Q47349591Nucleic acid aptamer-based methods for diagnosis of infections
Q37857036Nucleic acid based molecular devices
Q37806645Nucleic acid-based fluorescent probes and their analytical potential.
Q36328830Nucleic-Acid-binding chromophores as efficient indicators of aptamer-target interactions
Q47162133On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids
Q39288369On-chip regeneration of aptasensors for monitoring cell secretion
Q42674459One-step tumor detection from dynamic morphology tracking on aptamer-grafted surfaces
Q43793208Open-tubular capillary electrochromatography of bovine beta-lactoglobulin variants A and B using an aptamer stationary phase
Q31010768Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions -- an NMR structure and hydration study.
Q33752349Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition
Q38340731Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide
Q42867856Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures
Q38311927Probing high-affinity 11-mer DNA aptamer against Lup an 1 (β-conglutin).
Q38293960Programmable DNA scaffolds for spatially-ordered protein assembly
Q38328878Protein detection by nanopores equipped with aptamers
Q36404412Protein detection via direct enzymatic amplification of short DNA aptamers
Q52592141Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations.
Q33491273Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
Q38320550Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs
Q47664202Quantitative Analysis of Nucleic Acid Stability with Ligands Under High Pressure to Design Novel Drugs Targeting G-Quadruplexes
Q34401522RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles
Q40606140RNA aptamers selected against the receptor activator of NF-kappaB acquire general affinity to proteins of the tumor necrosis factor receptor family
Q38342284RNA aptamers specifically interact with the prion protein PrP.
Q64915572Raman Spectroscopy and Aptamers for a Label-Free Approach: Diagnostic and Application Tools.
Q38303315Rational design of a structure-switching DNA aptamer for potassium ions
Q38102886Recent progress in G-quadruplex DNA in deep eutectic solvent.
Q27642854Recognition of planar and nonplanar ligands in the malachite green-RNA aptamer complex
Q27730882Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG)
Q42320172Regulation of photosensitisation processes by an RNA aptamer
Q38324832Reversible regulation of aptamer activity with effector-responsive hairpin oligonucleotides
Q35958678SELEX Modifications and Bioanalytical Techniques for Aptamer-Target Binding Characterization.
Q38166624Selecting Molecular Recognition. What Can Existing Aptamers Tell Us about Their Inherent Recognition Capabilities and Modes of Interaction?
Q35674292Selection and Characterization of DNA Aptamers Targeting All Four Serotypes of Dengue Viruses
Q36690512Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics
Q39455745Selective recognition of co-assembled thrombin aptamer and docetaxel on mesoporous silica nanoparticles against tumor cell proliferation
Q38599130Self-Assembled Smart Nanocarriers for Targeted Drug Delivery
Q38318732Self-assembled DNA-based giant thrombin nanoparticles for controlled release.
Q51792748Sensitive and reusable electrochemiluminescent aptasensor achieved with diblock oligonucleotides immobilized solely through preferential adenine-Au interaction.
Q57793783Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Q33259103Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease
Q35657036Single-Round Patterned DNA Library Microarray Aptamer Lead Identification
Q36611086Single-molecule investigation of G-quadruplex using a nanopore sensor
Q90250206Single-round isolation of diverse RNA aptamers from a random sequence pool
Q36299184Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative
Q38291915Site specific self-cleavage of certain assemblies of G-quadruplex.
Q38295241Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
Q38322640Small molecule signals that direct the route of a molecular cargo
Q36827819Sodium and potassium ion-promoted formation of supramolecular aggregates of 2'-deoxyguanylyl-(3'-5')-2'-deoxyguanosine
Q42951468Sole and Stable RNA Duplexes of G-Rich Sequences Located in the 5′-Untranslated Region of Protooncogenes
Q36676726Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution
Q27729935Solution structure of the Tetrahymena telomeric repeat d(T2G4)4 G-tetraplex
Q27732554Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats
Q38040981Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications.
Q38310664Specific loop modifications of the thrombin-binding aptamer trigger the formation of parallel structures
Q89948887Splitting aptamers and nucleic acid enzymes for the development of advanced biosensors
Q38297955Stability and binding properties of a modified thrombin binding aptamer
Q38303873Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions
Q41680421Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands.
Q38287623Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry
Q57773676Structural Polymorphism of Telomeric DNA Regulated by pH and Divalent Cation
Q46681396Structural diversity and isomorphism of hydrogen-bonded base interactions in nucleic acids
Q40396884Structural probing and damage selection of citrulline- and arginine-specific RNA aptamers identify base positions required for binding
Q31013237Structural studies on LNA quadruplexes
Q38326875Structural study of thrombin binding DNA aptamers by the circular dichroism
Q38357763Structural transition from antiparallel to parallel G-quadruplex of d(G4T4G4) induced by Ca2+.
Q41385028Structure and target interaction of a G-quadruplex RNA-aptamer
Q33939574Structure in nascent RNA leads to termination of slippage transcription by T7 RNA polymerase
Q38304014Structure variations of TBA G-quadruplex induced by 2'-O-methyl nucleotide in K+ and Ca2+ environments
Q27622154Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA
Q36978525Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
Q90332791Studying DNA G-Quadruplex Aptamer by 19F NMR
Q92482228Supramolecular Aptamers on Graphene Oxide for Efficient Inhibition of Thrombin Activity
Q39715618Synthesis and characterization of 8-methoxy-2'- deoxyadenosine-containing oligonucleotides to probe the syn glycosidic conformation of 2'-deoxyadenosine within DNA.
Q37580395Synthesis and structural characterization of stable branched DNA g-quadruplexes using the trebler phosphoramidite.
Q38340401Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker
Q37709561Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes
Q34579783Target-responsive DNA-capped nanocontainer used for fabricating universal detector and performing logic operations
Q38335625Tetraplex structure formation in the thrombin-binding DNA aptamer by metal cations measured by vibrational spectroscopy
Q36675591The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing 5-(1-pentynyl)-2'-deoxyuridine
Q24793800The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides
Q27619445The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4))
Q89707146The influencing factors and functions of DNA G-quadruplexes
Q36538501The role of thrombin exosites I and II in the activation of human coagulation factor V.
Q38319495The selection of DNA aptamers for two different epitopes of thrombin was not due to different partitioning methods.
Q27639381The solution structure of d(G(4)T(4)G(3))(2): a bimolecular G-quadruplex with a novel fold
Q27933905The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA.
Q52676609Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative.
Q91646149Thrombin Aptamer-Modified Metal-Organic Framework Nanoparticles: Functional Nanostructures for Sensing Thrombin and the Triggered Controlled Release of Anti-Blood Clotting Drugs
Q90430030Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps
Q30479872Thrombin-Binding Aptamer Quadruplex Formation: AFM and Voltammetric Characterization.
Q27670605Thrombin-aptamer recognition: a revealed ambiguity
Q37653016Thrombin-mediated transcriptional regulation using DNA aptamers in DNA-based cell-free protein synthesis
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