IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway

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IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway is …
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scholarly articleQ13442814

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P356DOI10.1038/SREP15701
P932PMC publication ID4637890
P698PubMed publication ID26549519
P5875ResearchGate publication ID284104331

P2093author name stringZhuo Zhou
Jianqin He
Beibei Qin
Shiping Ding
Chunlan Yan
P2860cites workAtg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes.Q51815815
Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.Q55033997
BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cellsQ60394831
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi networkQ24522511
TOR signaling in growth and metabolismQ27860757
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cellsQ28138966
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Regulation mechanisms and signaling pathways of autophagyQ29547416
Autophagy as a regulated pathway of cellular degradationQ29547914
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAGQ29615716
Self-eating and self-killing: crosstalk between autophagy and apoptosisQ29617748
The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activationQ33556218
17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence.Q33962903
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasiaQ35935777
Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathwayQ36060322
Interleukin-6: from basic science to medicine--40 years in immunologyQ36072403
Bcl-2 inhibition of autophagy: a new route to cancer?Q36422636
Autophagy as an immune defense mechanismQ36510398
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivoQ36647747
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activityQ39256099
AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathwayQ39327200
Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cellsQ39375270
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditionsQ39680852
Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotidesQ40109913
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cellsQ40667540
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cellsQ40694264
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathwayQ40789651
Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytQ40795750
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cellsQ42866546
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)15701
P577publication date2015-11-09
P1433published inScientific ReportsQ2261792
P1476titleIL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway
P478volume5

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cites work (P2860)
Q38719033Age-Dependent Effects of ALK5 Inhibition and Mechanism of Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury.
Q40534430Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.
Q89810172ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy
Q39683625IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway
Q47660154IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.
Q90622578IL-6 deficiency attenuates p53 protein accumulation in aged male mouse hippocampus
Q89722880Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures
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Q94009272Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3
Q90231153Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
Q89978268Remote Ischemic Preconditioning induces Cardioprotective Autophagy and Signals through the IL-6-Dependent JAK-STAT Pathway
Q89896113Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish
Q61444104The relationship between autophagy and the immune system and its applications for tumor immunotherapy