A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia

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A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/JCBFM.2015.115
P932PMC publication ID4640320
P698PubMed publication ID26036941

P50authorLuc PellerinQ41241332
Lorenz HirtQ43244899
P2093author name stringAlfred Buck
Bruno Weber
Matthias T Wyss
Konstantin Drandarov
Katia Rosafio
Ximena Castillo
P2860cites workIdentification of putative mammalian D-lactate dehydrogenase enzymesQ24301724
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Oligodendroglia metabolically support axons and contribute to neurodegeneration.Q34032818
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Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathwayQ34950419
Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brainQ35736196
Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathwayQ35858747
Monocarboxylate transporters in the central nervous system: distribution, regulation and function.Q36161586
Lactate transport and receptor actions in cerebral malariaQ39215113
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrityQ39492965
Enhanced cerebral expression of MCT1 and MCT2 in a rat ischemia model occurs in activated microglial cellsQ39859113
Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetateQ40057390
Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stressQ40385439
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Regulation of oligodendrocyte development and myelination by glucose and lactateQ42632174
3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes.Q42720352
Neuroprotective role of lactate after cerebral ischemiaQ43292770
Protection by pyruvate against transient forebrain ischemia in rats.Q43757489
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimentalQ43825328
MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brainQ43970047
A femoral arteriovenous shunt facilitates arterial whole blood sampling in animals.Q43987715
Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulationQ44328959
Quantitative cerebral blood flow measurements in the rat using a beta-probe and H2 15O.Q44685266
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.Q45169327
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brainQ45840054
A semiautomated method for measuring brain infarct volume.Q45954002
Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trialQ46067965
Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patientsQ46354513
Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice culturesQ46591598
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity.Q46599270
Preferential utilization of acetate by astrocytes is attributable to transport.Q47892655
Neuroprotective effects of lactate in brain ischemia: dependence on anesthetic drugsQ48100624
New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administrationQ48115530
Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat.Q48312362
A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor.Q48610328
Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism.Q50972217
Sensitive Reduction in 14C-acetate Uptake in a Short-term Ischemic Rat BrainQ60430785
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophagesQ60687194
Lactate-Supported Synaptic Function in the Rat Hippocampal Slice PreparationQ68381532
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exerciseQ84916971
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectcerebral infarctionQ1209150
P304page(s)1561-1569
P577publication date2015-06-03
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleA probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia
P478volume35

Reverse relations

cites work (P2860)
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Q47876822l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro

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