Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport

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Bifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1271513K
P356DOI10.1371/JOURNAL.PONE.0171513
P932PMC publication ID5300169
P698PubMed publication ID28182699

P2093author name stringKentaro Tsuji-Naito
Michiko Kudo
Kumiko Kobayashi-Nakamura
P2860cites workGriscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)Q24313435
Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden miceQ24555217
Signaling Pathways in MelanogenesisQ26739678
Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumorsQ26747756
Update on the regulation of mammalian melanocyte function and skin pigmentationQ28237643
Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transportQ28269029
Melanin pigmentation in mammalian skin and its hormonal regulationQ28283615
Novel MITF targets identified using a two-step DNA microarray strategyQ28303403
Identification of an organelle receptor for myosin-VaQ28504759
The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cellsQ28589486
Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation.Q50554165
Manassantin B inhibits melanosome transport in melanocytes by disrupting the melanophilin-myosin Va interaction.Q52628289
5,7-dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP-dependent signalling.Q54602069
Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein geneQ57338477
Antioxidant and prooxidant behavior of flavonoids: structure-activity relationshipsQ73268875
Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate productsQ79544053
Novel myosin heavy chain encoded by murine dilute coat colour locusQ28590446
A mutation in Rab27a causes the vesicle transport defects observed in ashen miceQ28594384
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis GeorgiQ33880655
Determination of melanin synthetic pathways.Q34029446
Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathwaysQ34155733
Walking to work: roles for class V myosins as cargo transportersQ34238805
L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functionsQ35624374
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymesQ36119125
Melanocyte biology and skin pigmentationQ36742011
Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanomaQ37198853
"Transcription physiology" of pigment formation in melanocytes: central role of MITF.Q37702420
Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.Q37934725
Molecular Network Associated with MITF in Skin Melanoma Development and ProgressionQ37951952
Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders.Q38256452
Curcumin does not switch melanin synthesis towards pheomelanin in B16F10 cellsQ38940393
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expressionQ39128321
Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytesQ39171077
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytesQ39791257
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.Q40492183
Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome functionQ40596515
{alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism.Q43099218
Slac2-a/melanophilin contains multiple PEST-like sequences that are highly sensitive to proteolysisQ44897879
Inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by flavonoids isolated from the Chinese herb scutellariae radix (Huang Qin).Q46082353
Antioxidant activity of methanol extracts obtained from Plantago species.Q46380269
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectScutellaria baicalensisQ803769
P304page(s)e0171513
P577publication date2017-02-09
P1433published inPLOS OneQ564954
P1476titleBifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport
P478volume12

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cites work (P2860)
Q92663109Optimization of Ultrasonic Flavonoid Extraction from Saussurea involucrate, and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes
Q91846291Skullcapflavone I suppresses proliferation of human lung cancer cells via down-regulating microRNA-21

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