Echinocandin Resistance in Candida

scientific article

Echinocandin Resistance in Candida is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/CID/CIV791
P932PMC publication ID4643482
P698PubMed publication ID26567278
P5875ResearchGate publication ID283790812

P2093author name stringDavid S Perlin
P2860cites workA drug-sensitive genetic network masks fungi from the immune systemQ21131621
Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofunginQ24674839
Micafungin: an evidence-based review of its place in therapyQ27014780
The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growthQ27934297
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurinQ28475818
Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrataQ28483785
Echinocandin resistance: an emerging clinical problem?Q28544739
Hidden killers: human fungal infectionsQ29617101
Mucosal damage and neutropenia are required for Candida albicans disseminationQ33320189
Stimulation of chitin synthesis rescues Candida albicans from echinocandins.Q33326983
Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivityQ33365853
Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazoleQ33622915
Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria.Q33830384
Breakpoints for antifungal agents: an update from EUCAST focussing on echinocandins against Candida spp. and triazoles against Aspergillus spp.Q38195132
Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient managementQ38254290
Mechanisms of Antifungal Drug ResistanceQ38266675
A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibilityQ39686624
Role of matrix β-1,3 glucan in antifungal resistance of non-albicans Candida biofilms.Q39767233
The epidemiology of Candida colonization and invasive candidiasis in a surgical intensive care unit where fluconazole prophylaxis is utilized: follow-up to a randomized clinical trialQ39878330
Development of echinocandin-resistant Candida albicans candidemia following brief prophylactic exposure to micafungin therapyQ40207847
Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strainsQ40750655
Risk factors for candidemia in patients with acute lymphocytic leukemiaQ40751044
Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistanceQ41184732
Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpointsQ41787736
In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance.Q41810114
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans.Q41810708
Fungal echinocandin resistance.Q41848811
Use of micafungin as a surrogate marker to predict susceptibility and resistance to caspofungin among 3,764 clinical isolates of Candida by use of CLSI methods and interpretive criteriaQ41908678
Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans.Q41990022
Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiaeQ42035911
Aneuploidy and isochromosome formation in drug-resistant Candida albicansQ42113364
The impact of new epidemiological cutoff values on Candida glabrata resistance rates and concordance between testing methodsQ42222742
Systemic antifungal prophylaxis after hematopoietic stem cell transplantation: a meta-analysisQ42232412
Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpointQ42545839
Candida glabrata intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscessesQ42735489
Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp.Q42929579
Use of anidulafungin as a surrogate marker to predict susceptibility and resistance to caspofungin among 4,290 clinical isolates of Candida by using CLSI methods and interpretive criteriaQ43125888
Candida colonisation as a source for candidaemiaQ44703269
Emergence of echinocandin-resistant Candida spp. in a hospital setting: a consequence of 10 years of increasing use of antifungal therapy?Q46908055
EUCAST technical note on anidulafunginQ47577071
A 1-year prospective survey of candidemia in Italy and changing epidemiology over one decadeQ61024374
In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida speciesQ33876423
Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolatesQ33938068
Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistanceQ34058099
Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignanciesQ34301513
Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patientsQ34529026
Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapyQ34754956
Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.Q34936576
Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafunginQ35065859
Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.Q35129428
Candida glabrata mutants demonstrating paradoxical reduced caspofungin susceptibility but increased micafungin susceptibilityQ35139474
New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium speciesQ35139501
Importance of Candida-bacterial polymicrobial biofilms in diseaseQ35490098
Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivoQ35666505
Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrataQ35867789
Differential in vivo activities of anidulafungin, caspofungin, and micafungin against Candida glabrata isolates with and without FKS resistance mutationsQ35941237
Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemiaQ35947465
Integrative studies put cell wall synthesis on the yeast functional map.Q35958175
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolatesQ36095337
The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrataQ36172500
Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011.Q36423773
Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin.Q36785949
Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints.Q36845482
Resistance to echinocandin-class antifungal drugsQ36849595
Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrationsQ36856930
Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection.Q36933000
Caspofungin modulates inflammatory responses to Aspergillus fumigatus through stage-specific effects on fungal beta-glucan exposure.Q36983268
Caspofungin as primary antifungal prophylaxis in stem cell transplant recipients.Q37015953
Echinocandin and triazole antifungal susceptibility profiles for clinical opportunistic yeast and mold isolates collected from 2010 to 2011: application of new CLSI clinical breakpoints and epidemiological cutoff values for characterization of geogrQ37036246
Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.Q37124005
Investigation of the sequence of colonization and candidemia in nonneutropenic patientsQ37165273
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?Q37335747
Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight Candida species and the CLSI M27-A3 broth microdilution method.Q37544819
Current perspectives on echinocandin class drugsQ37554055
Micafungin: a review of its use in the prophylaxis and treatment of invasive Candida infectionsQ38053482
P407language of work or nameEnglishQ1860
P304page(s)S612-7
P577publication date2015-12-01
P1433published inClinical Infectious DiseasesQ5133764
P1476titleEchinocandin Resistance in Candida
P478volume61 Suppl 6