Employment of substandard antiemetic prophylaxis in recent trials of chemotherapy-induced nausea and vomiting

scientific article

Employment of substandard antiemetic prophylaxis in recent trials of chemotherapy-induced nausea and vomiting is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1345/APH.1G079
P698PubMed publication ID16204394

P2093author name stringMark T Holdsworth
Thuy Vo-Nguyen
P2860cites workThe continuing unethical use of placebo controlsQ28244803
Effective cross-over to granisetron after failure to ondansetron, a randomized double blind study in patients failing ondansetron plus dexamethasone during the first 24 hours following highly emetogenic chemotherapyQ28364205
Phase I study of intravenous PSC-833 and doxorubicin: reversal of multidrug resistanceQ32063216
Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. American Society of Clinical OncologyQ33880234
Equipoise and the ethics of clinical researchQ34050273
The ethical analysis of riskQ34228763
Antiemetic prescription in Italian breast cancer patients submitted to adjuvant chemotherapyQ35568094
Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonistsQ36431212
Are more antiemetic trials with a placebo necessary? Report of patient data from randomized trials of placebo antiemetics with cisplatinQ36832481
Denial of effective treatment and poor quality of clinical information in placebo controlled trials of ondansetron for postoperative nausea and vomiting: a review of published trialsQ36905066
Combination of transcutaneous electrical nerve stimulation and ondansetron in preventing cisplatin-induced emesisQ39416550
Dexamethasone, paclitaxel, etoposide, cyclophosphamide (d-TEC) and G-CSF for stem cell mobilisation in multiple myelomaQ40597777
Views of American oncologists about the purposes of clinical trialsQ40614974
Comparative efficacy of three 5-HT3 antagonists (granisetron, ondansetron, and tropisetron) plus dexamethasone for the prevention of cisplatin-induced acute emesis: a randomized crossover studyQ42624694
Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administrationQ43516796
Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone aloneQ43543624
Ondansetron plus metopimazine compared with ondansetron plus metopimazine plus prednisolone as antiemetic prophylaxis in patients receiving multiple cycles of moderately emetogenic chemotherapyQ43562737
Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist, L-754,030, with ondansetron for the prevention of cisplatin-induced emesisQ43582725
Comparison of tropisetron and granisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapyQ43735498
Randomised comparison of ondansetron plus dexamethasone with dexamethasone alone for the control of delayed cisplatin-induced emesisQ43807560
Double-blind comparative trial of oral ondansetron versus oral granisetron versus IV ondansetron in the prevention of nausea and vomiting associated with highly emetogenic preparative regimens prior to stem cell transplantationQ43835952
Implementing evidence based antiemetic guidelines in the oncology setting: results of a 4-month prospective intervention studyQ43837397
Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869.Q44062377
Clinical evaluation of Ramosetron injections in the treatment of cisplatin-induced nausea and vomitingQ44092953
Ramosetron for the prevention of cisplatin-induced acute emesis: a prospective randomized comparison with granisetronQ44092956
Combination therapy with granisetron, methylprednisolone and droperidol as an antiemetic prophylaxis in CDDP-induced delayed emesis for gynecologic cancerQ44232936
A randomized double-blind trial to compare the clinical efficacy of granisetron with metoclopramide, both combined with dexamethasone in the prophylaxis of chemotherapy-induced delayed emesisQ44299829
Reduced maintenance of complete protection from emesis for women during chemotherapy cyclesQ44308882
Establishing the dose of the oral NK1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting.Q44415307
Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin AmericaQ44464294
Functional relevance of antiemetic control. Experience using the FLIE questionnaire in a randomised study of the NK-1 antagonist aprepitant.Q44490963
Randomized study of dexamethasone treatment for delayed emesis, anorexia and fatigue induced by irinotecanQ44502218
Tropisetron and dexamethasone administered twice daily for the prevention of acute emesis in patients treated with continuous infusion of Cisplatin-Doxorubicin and high-dose Ifosfamide over 48, 24, and 120 hoursQ44529396
Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetronQ44592616
High-dose i.v. granisetron for the prevention of chemotherapy-induced emesis: cardiac safety and tolerabilityQ44613268
The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin--the Aprepitant Protocol 052 StQ44618271
Addition of the oral NK1 antagonist aprepitant to standard antiemetics provides protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapyQ44618275
Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetronQ44667127
A double-blind, crossover, randomized comparison of granisetron and ramosetron for the prevention of acute and delayed cisplatin-induced emesis in patients with gastrointestinal cancer: is patient preference a better primary endpoint?Q44690541
The oral NK(1) antagonist, aprepitant, given with standard antiemetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: a combined analysis of two randomised, placebo-controlled phase III clinicalQ44744702
Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: a dose-ranging clinical studyQ44754098
Randomized, double-blind, dose-finding study of dexamethasone in preventing acute emesis induced by anthracyclines, carboplatin, or cyclophosphamide:.Q44765706
Does increasing the steroid dose enhance the efficacy of the antiemetic combination of granisetron and methylprednisolone in gynecologic cancer patients--a randomized studyQ44809437
Efficacy of droperidol in the prevention of cisplatin-induced delayed emesis: a double-blind, randomised parallel studyQ44864323
Control of acute cisplatin-induced emesis over repeat courses of chemotherapy. Italian Group for Antiemetic Research.Q51025001
The integral role of clinical research in clinical care.Q53392261
The therapeutic orientation to clinical trials.Q53392264
Psychiatry. Are placebo-controlled drug trials ethical?Q53522579
Management of cyclophosphamide-induced emesis over repeat courses.Q53622835
Randomized, multicenter comparison of oral granisetron and oral ondansetron for emetogenic chemotherapy.Q53901789
On the receiving end--patient perception of the side-effects of cancer chemotherapy.Q55062718
Efficacy and safety of oral granisetron versus i.v. granisetron in patients undergoing peripheral blood progenitor cell and bone marrow transplantationQ56890355
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1903-1910
P577publication date2005-10-04
P1433published inAnnals of PharmacotherapyQ4767858
P1476titleEmployment of substandard antiemetic prophylaxis in recent trials of chemotherapy-induced nausea and vomiting
P478volume39

Reverse relations

cites work (P2860)
Q55514384Acute chemotherapy-induced nausea and vomiting in children with cancer: Still waiting for a common consensus on treatment.
Q34450534Aprepitant: the evidence for its place in the prevention of chemotherapy-induced nausea and vomiting.

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