The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry

scientific article

The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M115.657346
P932PMC publication ID4646249
P698PubMed publication ID26354436

P50authorNicholas S EyreQ39999041
Andrew R. LloydQ44958229
Rowena A BullQ56400255
Michael R BeardQ60601244
Karla HelbigQ61087945
Auda A. EltahlaQ39403960
P2093author name stringErin M McCartney
Sumudu K Narayana
P2860cites workIFITM3 inhibits influenza A virus infection by preventing cytosolic entryQ21090493
Evolution of vertebrate interferon inducible transmembrane proteinsQ21266712
IFITM proteins restrict viral membrane hemifusionQ21558779
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanismsQ24302747
IFITM proteins restrict antibody-dependent enhancement of dengue virus infectionQ24311739
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effectorQ24316159
Molecular analysis of a human interferon-inducible gene familyQ24323277
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virusQ24337838
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33Q24338873
ISG56 and IFITM1 proteins inhibit hepatitis C virus replicationQ24339446
A diverse range of gene products are effectors of the type I interferon antiviral responseQ24626018
Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3Q24626267
Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation.Q40560162
IFITM1 is a tight junction protein that inhibits hepatitis C virus entryQ41844055
The IFITM proteins inhibit HIV-1 infectionQ24629626
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5AQ24632380
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virusQ24645420
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virusQ24658111
IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusionQ27329190
Robust hepatitis C virus infection in vitroQ27470013
Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cellsQ27472846
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
Endocytic Rab proteins are required for hepatitis C virus replication complex formationQ27490939
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Bril: a novel bone-specific modulator of mineralizationQ28580591
Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitinationQ28588118
The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localizationQ30422163
Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection.Q30576516
The SR-BI partner PDZK1 facilitates hepatitis C virus entry.Q33719403
Identification of an endocytic signal essential for the antiviral action of IFITM3.Q33784795
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycleQ33893794
A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virusQ34010288
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infectionsQ34046037
The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entryQ34340346
S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virusQ36003903
Hepatitis C virus infection modulates expression of interferon stimulatory gene IFITM1 by upregulating miR-130A.Q36246282
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replicationQ36978590
Global control of hepatitis C: where challenge meets opportunityQ37077112
Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradationQ37327802
The small interferon-induced transmembrane genes and proteinsQ37821933
Antiviral resistance and direct-acting antiviral agents for HCV.Q38063185
What does S-palmitoylation do to membrane proteins?Q38095680
Virology and cell biology of the hepatitis C virus life cycle: an updateQ38274457
IFITM-Family Proteins: The Cell's First Line of Antiviral DefenseQ38323041
Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus.Q39148017
Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.Q39200590
P433issue43
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
transmembrane proteinQ424204
Hepatitis C virusQ708693
P304page(s)25946-25959
P577publication date2015-09-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry
P478volume290

Reverse relations

cites work (P2860)
Q52430897A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Q58596596A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles
Q92527731Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay
Q38635092Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection
Q63246712Antiviral Protection by IFITM3 In Vivo
Q63246519Antiviral Role of IFITM Proteins in Classical Swine Fever Virus Infection
Q47094466Characterization and anti-inflammation role of swine IFITM3 gene
Q64374802Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro
Q30276614Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection
Q91364086Exosomal Interferon-Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti-Hepatitis B Virus Efficacy of Exogenous Interferon Alpha
Q64989066Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity.
Q57792998Functional mapping of regions involved in the negative imprinting of virion particles infectivity and in target cell protection by the Interferon-Induced Transmembrane Protein 3 (IFITM3) against HIV-1
Q96343106Grouper interferon-induced transmembrane protein 3 (IFITM3) inhibits the infectivity of iridovirus and nodavirus by restricting viral entry
Q26775018Hepatitis C virus infection and thyroid autoimmune disorders: A model of interactions between the host and the environment
Q112052444IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Q59352250IFITM1 expression is crucial to gammaherpesvirus infection, in vivo
Q38707618IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21.
Q92855169IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells
Q91045937IFITM3 directly engages and shuttles incoming virus particles to lysosomes
Q38156590IFITM3 requires an amphipathic helix for antiviral activity.
Q55256172Identification of key genes and pathways in regulating immune‑induced diseases of dendritic cells by bioinformatic analysis.
Q92028460Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
Q41928655Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs
Q62898063Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane
Q91813039Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection
Q90580146Intrahepatic Viral Kinetics during Direct-Acting Antivirals for Hepatitis C in HIV Co-infection:The ACTG A5335S Substudy
Q42369135Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.
Q28834348Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation
Q46197224More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins
Q30145642Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika
Q61815883Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection
Q30361340Rhesus macaque IFITM3 gene polymorphisms and SIV infection.
Q98664289S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity
Q40958940S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling
Q47546996SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses
Q97692496Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer
Q27928046Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
Q90567199Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology
Q52367862The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection.
Q37252899The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses
Q92879297The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis
Q57106448The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses
Q47592878The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity
Q90393978Topology, Antiviral Functional Residues and Mechanism of IFITM1
Q89840861Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus
Q33860964Viperin is an important host restriction factor in control of Zika virus infection
Q47099548miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1).

Search more.