Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism

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Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.18632/AGING.100482
P932PMC publication ID3461341
P698PubMed publication ID22935594

P2093author name stringLeBris S Quinn
Charles T Lutz
P2860cites workInterleukin-15 and its soluble receptor mediate the response to infliximab in patients with Crohn's diseaseQ83058286
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Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.Q41893697
Adiponectin is a negative regulator of NK cell cytotoxicity.Q42494633
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Chronic high fat feeding attenuates load-induced hypertrophy in mice.Q43263022
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TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humansQ43505439
The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo.Q43648190
Resistin, central obesity, and type 2 diabetes.Q43865215
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A programmed switch from IL-15- to IL-2-dependent activation in human NK cells.Q47884291
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Muscles and their myokines.Q48943557
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No requirement of trans presentations of IL-15 for human CD8 T cell proliferation.Q51034844
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T-ing up inflammation in fatQ58197131
IL-15 is an essential mediator of peripheral NK-cell homeostasisQ58478746
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Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy populationQ81103628
The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage functionQ81224629
Resistin, an adipokine with potent proinflammatory propertiesQ81672242
Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged miceQ81803366
Fifth phase of the epidemiologic transition: the age of obesity and inactivityQ82494700
Skeletal muscle NAMPT is induced by exercise in humansQ33589034
Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expressionQ33624343
Aging of the innate immune systemQ33666891
Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivoQ33760403
NK and NK/T cells in human senescenceQ33846328
Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general populationQ33928216
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticityQ33934522
Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammationQ33946323
Sarcopenic obesity: does muscle loss cause fat gain? Lessons from rheumatoid arthritis and osteoarthritis.Q33949591
Correlation between serum resistin level and adiposity in obese individualsQ33967739
The functional characterization of interleukin-10 receptor expression on human natural killer cells.Q34294025
Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primatesQ34369832
Excess deaths associated with underweight, overweight, and obesityQ34412581
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.Q34426034
Adipose tissues as an ancestral immune organ: site-specific change in obesity.Q34426141
Interleukin 6 as a key regulator of muscle mass during cachexiaQ34727530
Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adultsQ34765436
Normalizing a hyperactive mTOR initiates muscle growth during obesityQ34852371
Age-related modifications in circulating IL-15 levels in humansQ34894566
Inflammatory markers in population studies of agingQ34995451
Interleukin-15 administration improves diaphragm muscle pathology and function in dystrophic mdx miceQ35083822
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissueQ35147250
Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cellsQ35175008
One size may not fit all: anti-aging therapies and sarcopeniaQ35740777
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serumQ36079820
Systemic inflammation and insulin sensitivity in obese IFN-γ knockout miceQ36278695
Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient MiceQ36370673
In vivo survival and homeostatic proliferation of natural killer cells.Q36370683
Cachexia: pathophysiology and clinical relevanceQ36442937
Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study.Q36538004
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentationQ36640049
Interleukin-15 antagonizes muscle protein waste in tumour-bearing ratsQ36642208
Association between muscular strength and mortality in men: prospective cohort study.Q36755864
Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body compositionQ36914800
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpeptideQ172847
sarcopeniaQ1787939
cellQ7868
hormoneQ11364
adipokineQ2638593
cellular senescenceQ9075999
obesityQ12174
hemic and immune systemsQ70202933
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)535-546
P577publication date2012-08-01
P1433published inAgingQ2845875
P1476titleSarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism
P478volume4

Reverse relations

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