Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1

scientific article

Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1006235
P932PMC publication ID5342271
P698PubMed publication ID28235087

P50authorStuart C. RayQ7626381
Ramy El-DiwanyQ56883476
Madeleine C MankowskiQ58208041
Valerie J KinchenQ88497172
Justin R BaileyQ96257761
Lisa N WasilewskiQ125310332
Jillian K BradyQ125310360
P2093author name stringBen Murrell
Anna E Snider
William O Osburn
P2860cites workCharacterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81.Q22010245
MEGA6: Molecular Evolutionary Genetics Analysis version 6.0Q24498082
MUSCLE: multiple sequence alignment with high accuracy and high throughputQ24613456
Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 BindingQ27477468
Viral Sequence Evolution in Acute Hepatitis C Virus InfectionQ27484985
CD8 Epitope Escape and Reversion in Acute HCV InfectionQ27485189
Cellular immune selection with hepatitis C virus persistence in humansQ27485219
Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant virusesQ27485952
Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus InfectivityQ27488430
Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C VirusQ27490467
Hepatitis C Virus E2 Envelope Glycoprotein Core StructureQ27680704
Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodiesQ27684112
The rapid generation of mutation data matrices from protein sequencesQ27860880
Genetic diversity and evolution of hepatitis C virus--15 years onQ29547888
Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalenceQ29616009
Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and GenotypesQ29619748
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal AntibodiesQ30383939
Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responsesQ33707246
Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infectionQ33853655
Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoproteinQ33913588
Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virusQ33955998
The natural history of hepatitis C virus infection: host, viral, and environmental factorsQ33974693
Prospective evaluation of community-acquired acute-phase hepatitis C virus infectionQ33986385
Humoral immune response in acute hepatitis C virus infectionQ33989160
Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis C virus E2 glycoprotein encompassing amino acids 412-423Q34047477
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virusQ34228030
Community Outbreak of HIV Infection Linked to Injection Drug Use of Oxymorphone--Indiana, 2015.Q34474460
Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralizationQ34594986
Broadly neutralizing antibodies abrogate established hepatitis C virus infectionQ35032263
Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistanceQ35242585
Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutationsQ35274913
Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustionQ35741969
Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoproteinQ36506935
Broad Anti-Hepatitis C Virus (HCV) Antibody Responses Are Associated with Improved Clinical Disease Parameters in Chronic HCV InfectionQ36811958
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies.Q37611842
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodiesQ37629584
Current progress in development of hepatitis C virus vaccines.Q38120201
The mechanism of HCV entry into host cellsQ38321419
Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment stepQ38335402
A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization Resistance.Q38809451
Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422.Q39062848
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C VirusQ39602767
Increases in hepatitis C virus infection related to injection drug use among persons aged ≤30 years - Kentucky, Tennessee, Virginia, and West Virginia, 2006-2012.Q40278327
Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infectionQ40341996
Hepatitis C virus resistance to broadly neutralizing antibodies measured using replication-competent virus and pseudoparticlesQ40527984
Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.Q42213859
Hepatitis C in the United StatesQ42992102
Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research GroupQ42993140
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challengeQ43048336
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)e1006235
P577publication date2017-02-24
P1433published inPLOS PathogensQ283209
P1476titleExtra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1
P478volume13

Reverse relations

cites work (P2860)
Q92964702A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor
Q59351582Approaches, Progress, and Challenges to Hepatitis C Vaccine Development
Q91862927Broadly Neutralizing Antibodies Targeting New Sites of Vulnerability in Hepatitis C Virus E1E2
Q59349176Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?
Q90134557Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies
Q56395915Defining Breadth of Hepatitis C Virus Neutralization
Q47548062Designing a B Cell-Based Vaccine against a Highly Variable Hepatitis C Virus
Q99407917Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
Q65002126Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay?
Q59349677Hepatitis C virus escape studies for human antibody AR3A reveals a high barrier to resistance and novel insights on viral antibody evasion mechanisms
Q59354660Hepatitis C virus escape studies for human monoclonal antibody AR4A reveal isolate-specific resistance and a high barrier to resistance
Q57490859Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Q63729516Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations
Q64065756Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
Q55282191Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine.
Q92592914Plasma deconvolution identifies broadly neutralizing antibodies associated with hepatitis C virus clearance
Q55657826Predicting the Effectiveness of Hepatitis C Virus Neutralizing Antibodies by Bioinformatic Analysis of Conserved Epitope Residues Using Public Sequence Data.
Q40088796Structure-Based Design of Hepatitis C Virus Vaccines that Elicit Neutralizing Antibody Responses to a Conserved Epitope
Q47236942Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms.

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