Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels

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Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1085/JGP.200509317
P932PMC publication ID2151482
P698PubMed publication ID16344323
P5875ResearchGate publication ID7426392

P50authorHuanghe YangQ47449834
P2093author name stringLei Hu
Jianmin Cui
Jingyi Shi
P2860cites workMolecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homologQ22009115
Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2Q22010884
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4Q22253242
A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxinQ22254019
Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brainQ24310769
Cloning and expression of a human large-conductance calcium-activated potassium channelQ24316164
Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brainQ24322785
A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channelsQ24329269
A novel calcium-sensing domain in the BK channelQ24532903
The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting statesQ24642378
Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsQ24681158
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channelQ27631193
Crystal structure and mechanism of a calcium-gated potassium channelQ27639064
Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpokeQ28242311
Human and rodent MaxiK channel beta-subunit genes: cloning and characterizationQ28293893
mSlo , a Complex Mouse Gene Encoding "Maxi" Calcium-Activated Potassium ChannelsQ28298176
A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channelsQ28511241
The versatility and universality of calcium signallingQ29547402
Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries.Q31917972
Mechanisms of hair cell tuningQ33547276
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit familyQ33903332
Regulation of intracellular free magnesium in central nervous system injuryQ33988759
Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertensionQ34037631
Interrelationship of magnesium and congestive heart failure.Q34097877
The large-conductance Ca2+-activated K+ channel is essential for innate immunityQ34301370
Functional role of the β subunit of high conductance calcium-activated potassium channelsQ34307062
Magnesium and cardiac arrhythmiasQ35049623
Magnesium and coronary heart diseaseQ35049627
Magnesium and heart failureQ35049631
Role of magnesium in the pathogenesis of hypertensionQ35049634
Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channelsQ35187669
Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activationQ35313534
Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channelsQ36411854
Separation of gating properties from permeation and block in mslo large conductance Ca-activated K+ channelsQ36411870
Differential effects of beta 1 and beta 2 subunits on BK channel activityQ36412648
Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membraneQ36434119
Competitive Mg2+ block of a large-conductance, Ca(2+)-activated K+ channel in rat skeletal muscle. Ca2+, Sr2+, and Ni2+ also blockQ36434786
Divalent cation block and competition between divalent and monovalent cations in the large-conductance K+ channel from Chara australisQ36435076
Hypothesis for a serine proteinase-like domain at the COOH terminus of Slowpoke calcium-activated potassium channelsQ36435808
Allosteric gating of a large conductance Ca-activated K+ channelQ36435872
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channelsQ36436425
Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivityQ36444716
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation siteQ36445217
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channelsQ36445229
Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.Q36445694
Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivityQ36447158
Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensingQ36447234
Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nervesQ36833371
Mechanisms of magnesium transportQ37739409
Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cellsQ38179410
Calcium-activated potassium channels and their role in secretionQ40140552
NMR studies of intracellular metal ions in intact cells and tissuesQ40181866
Magnesium transport across cell membranesQ40187739
Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pHQ40328586
A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells.Q40453556
Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains.Q40685545
Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channelQ40798532
An evolutionarily conserved binding site for serine proteinase inhibitors in large conductance calcium-activated potassium channelsQ41144695
Tracking presynaptic Ca2+ dynamics during neurotransmitter release with Ca2+-activated K+ channelsQ41736613
BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampusQ42458933
Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradientsQ42465201
Tonotopic variations of calcium signalling in turtle auditory hair cellsQ42486679
Calcium-activated potassium channels expressed from cloned complementary DNAsQ42607323
Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscleQ42620252
Multiple regulatory sites in large-conductance calcium-activated potassium channels.Q44111941
Properties of two calcium-activated hyperpolarizations in rat hippocampal neuronesQ44788685
Kinetic analysis of voltage- and ion-dependent conductances in saccular hair cells of the bull-frog, Rana catesbeianaQ45008765
Vasoregulation by the beta1 subunit of the calcium-activated potassium channelQ46410172
Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses.Q46459697
A model for electrical resonance and frequency tuning in saccular hair cells of the bull-frog, Rana catesbeianaQ46461080
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscleQ46544502
Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.Q47332663
Electrophysiological properties of BK channels in Xenopus motor nerve terminalsQ47870928
Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexesQ48046480
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo LocusQ48215777
Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neuronsQ48357057
Mechanism of magnesium activation of calcium-activated potassium channels.Q50486860
Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure.Q52541601
Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cellsQ52779025
Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels.Q53900509
Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle.Q54144432
Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neuronesQ59058265
Single channel recordings of Ca2+-activated K+ currents in rat muscle cell cultureQ59070211
Ca-dependent K channels with large unitary conductance in chromaffin cell membranesQ59070332
The Electrical Double Layer and the Theory of ElectrocapillarityQ60191441
Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channelsQ67530880
Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cellsQ67674833
Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channelQ69415355
Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondriaQ70277806
Differential modulation of large-conductance KCa channels by PKA in pregnant and nonpregnant myometriumQ71626256
Evidence that Ca(2+)-activated K+ channels participate in the regulation of pituitary prolactin secretionQ71674311
Relaxation of arterial smooth muscle by calcium sparksQ71768395
Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter releaseQ72096278
Localization of calcium signals by a mobile calcium buffer in frog saccular hair cellsQ72418257
Voltage clamp experiments on internally perfused giant axonsQ72695318
Transplantable sites confer calcium sensitivity to BK channelsQ77732702
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)35-49
P577publication date2005-12-12
P1433published inThe Journal of General PhysiologyQ1092259
P1476titleEffects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels
P478volume127

Reverse relations

cites work (P2860)
Q36965903Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
Q36593661An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels
Q43217494Ethanol Effect on BK Channels is Modulated by Magnesium
Q37493123Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring
Q35063533Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.
Q35581373Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated
Q36325854Mg2+ enhances voltage sensor/gate coupling in BK channels
Q36156951Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels
Q37223668Molecular mechanisms of BK channel activation
Q36729750State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels
Q27687169Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain
Q38045185The BK channel: a vital link between cellular calcium and electrical signaling.
Q37091597Transduction of voltage and Ca2+ signals by Slo1 BK channels
Q35052003Tuning magnesium sensitivity of BK channels by mutations.

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