beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel

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beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel is …
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scholarly articleQ13442814

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P356DOI10.1085/JGP.200609719
P8608Fatcat IDrelease_4id6xitd2zcxxhj6pmu6ldnd3q
P932PMC publication ID2151646
P698PubMed publication ID17698594
P5875ResearchGate publication ID6140250

P50authorFabiana Vasconcelos CamposQ47858681
Baron ChandaQ42753518
P2093author name stringFrancisco Bezanilla
Paulo S L Beirão
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Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channelQ48873859
Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Na+ channelsQ48962330
Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels.Q51821558
Allosteric interactions between scorpion toxin receptor sites on voltage-gated Na channels imply a novel role for weakly active components in arthropod venom.Q52670833
Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venomQ52719814
Preliminary spectroscopic characterization of six toxins from Latin American scorpionsQ56700294
Gating current experiments on frog nodes of Ranvier treated with Centruroides sculpturatus toxins or aconitineQ69003780
A quantitative description of membrane current and its application to conduction and excitation in nerveQ22337072
Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channelsQ24642407
Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathwayQ24684535
Structural analysis of Tityus serrulatus Ts1 neurotoxin at atomic resolution: insights into interactions with Na+ channelsQ27640552
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.Q33925844
A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axonQ34088219
Voltage-gated ion channels and gating modifier toxins.Q34161355
Potassium ion current in the squid giant axon: dynamic characteristicQ34349547
Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.Q34479240
The cooperative voltage sensor motion that gates a potassium channelQ34482244
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.Q35001630
Sodium and gating current time shifts resulting from changes in initial conditionsQ36408701
Shaker potassium channel gating. III: Evaluation of kinetic models for activationQ36411441
Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescenceQ36412182
Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurementsQ36412534
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activationQ36420417
Molecular kinetics of voltage-dependent Na+ channelsQ36431859
Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxinQ36435536
Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxinQ36435540
Structural implications of fluorescence quenching in the Shaker K+ channelQ36436115
Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxinQ36436376
Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.Q36436547
Immobilizing the moving parts of voltage-gated ion channelsQ36444725
Sodium Channel Gating: Models, Mimics, and ModifiersQ40135898
The kinetics of voltage-gated ion channelsQ40401722
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivationQ41608443
Inactivation of the sodium channel. II. Gating current experimentsQ41933393
P433issue3
P921main subjectvoltageQ25428
P304page(s)257-268
P577publication date2007-08-13
P1433published inThe Journal of General PhysiologyQ1092259
P1476titlebeta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel
P478volume130

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