Rosiglitazone improves insulin sensitivity and baroreflex gain in rats with diet-induced obesity

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Rosiglitazone improves insulin sensitivity and baroreflex gain in rats with diet-induced obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.112.194738
P932PMC publication ID3464031
P698PubMed publication ID22815534

P2093author name stringBelinda H McCully
Virginia L Brooks
Ding Zhao
P2860cites workUneven blunting of chronotropic baroreflexes in obese Zucker ratsQ42505160
Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigationQ43046058
Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart diseaseQ43068830
Attenuated baroreflex control of sympathetic nerve activity in obese Zucker rats by central mechanismsQ43138220
Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesityQ44669024
Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese ratsQ44870389
Development of hypertension in a rat model of diet-induced obesityQ44871004
AT1-receptor antagonism reverses the blood pressure elevation associated with diet-induced obesityQ46387477
Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazoneQ46425687
Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndromeQ46642993
Energy restriction enhances therapeutic efficacy of the PPARgamma agonist, rosiglitazone, through regulation of visceral fat gene expressionQ46758003
Augmentation of nitric oxide is crucial for the time-dependent effects of rosiglitazone on blood pressure and baroreflex function in ratsQ46842968
Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans.Q47288319
Endogenous ANG II supports lumbar sympathetic activity in conscious sodium-deprived rats: role of area postremaQ47747060
Insulin resistance and impaired baroreflex gain during pregnancyQ48271249
Impairment of sympathetic baroreceptor reflexes in obese Zucker ratsQ48572706
Spontaneous baroreflex sensitivity: towards an ideal index of cardiovascular risk.Q54306926
Characteristics of rat aortic baroreceptors with nonmedullated afferent nerve fibersQ67548681
Obese Zucker rats, though still normotensive, already have impaired chronotropic baroreflexesQ68061464
Reduced parasympathetic control of heart rate in obese dogsQ72006032
Sodium intake, angiotensin II receptor blockade, and baroreflex function in conscious ratsQ73086597
Differential frequency-dependent reflex integration of myelinated and nonmyelinated rat aortic baroreceptorsQ74820674
Graded and dynamic reflex summation of myelinated and unmyelinated rat aortic baroreceptorsQ78253021
Effect of pioglitazone on arterial baroreflex sensitivity and sympathetic nerve activity in patients with acute myocardial infarction and type 2 diabetes mellitusQ83505225
The mechanisms of action of PPARsQ28216953
Fat and beyond: the diverse biology of PPARgammaQ29615416
Adipocytes as regulators of energy balance and glucose homeostasisQ29619448
Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss.Q31829643
Pregnancy impairs baroreflex control of heart rate in rats: role of insulin sensitivityQ33686616
Glucose clamp technique: a method for quantifying insulin secretion and resistanceQ34191986
Role of the renin-angiotensin system in vascular inflammationQ34789029
A role for central nervous system PPAR-γ in the regulation of energy balanceQ34949080
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgammaQ35835330
Diet-induced obesity severely impairs myelinated aortic baroreceptor reflex responsesQ35994115
Modeling disease progression and rosiglitazone intervention in type 2 diabetic Goto-Kakizaki ratsQ35996694
Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerabilityQ36026409
Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinedionesQ36050852
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesityQ36073422
Blood pressure variability: its measurement and significance in hypertension.Q36094155
Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissueQ36141342
Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failureQ36288181
The many faces of PPARgammaQ36344625
Recent advances in the relationship between obesity, inflammation, and insulin resistance.Q36448850
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.Q36509300
Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleusQ36994179
Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculatureQ37085280
Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasisQ37106685
Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension.Q37150021
Local adipose tissue renin-angiotensin systemQ37161437
Dietary therapy for obesity: an emperor with no clothesQ37161882
Distinct functions of vascular endothelial and smooth muscle PPARgamma in regulation of blood pressure and vascular toneQ37468639
Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS.Q42454049
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
(RS)-rosiglitazoneQ424771
P304page(s)206-213
P577publication date2012-07-18
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleRosiglitazone improves insulin sensitivity and baroreflex gain in rats with diet-induced obesity
P478volume343

Reverse relations

cites work (P2860)
Q36923773Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin
Q35952693Baroreflex function in females: changes with the reproductive cycle and pregnancy
Q62828925Blunted sympathoinhibitory responses in obesity-related hypertension are due to aberrant central but not peripheral signalling mechanisms
Q39147191Chromogranin A Regulation of Obesity and Peripheral Insulin Sensitivity
Q90541320Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation
Q37234824Chronic baroreflex activation restores spontaneous baroreflex control and variability of heart rate in obesity-induced hypertension
Q33568792Development of attenuated baroreflexes in obese Zucker rats coincides with impaired activation of nucleus tractus solitarius
Q91761420Improved glucose homeostasis in male obese Zucker rats coincides with enhanced baroreflexes and activation of the nucleus tractus solitarius
Q34051403Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction.
Q37431571Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats
Q37342174Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias.
Q92690983Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features
Q35548908Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein e deficient mice

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