Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression

scientific article

Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TAAP.2007.08.028
P932PMC publication ID2153436
P698PubMed publication ID17950772
P5875ResearchGate publication ID5894501

P2093author name stringIvan Rusyn
Joseph G Ibrahim
Blair U Bradford
Michael L Cunningham
Oksana Kosyk
Pamela K Ross
Amanda M Burns
Pingping Qu
Courtney G Woods
P2860cites workRestriction beyond the restriction point: mitogen requirement for G2 passageQ21203560
Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferationQ23918430
Significance analysis of microarrays applied to the ionizing radiation responseQ24606608
Cluster analysis and display of genome-wide expression patternsQ24644463
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferatorsQ24652367
GoMiner: a resource for biological interpretation of genomic and proteomic dataQ24796534
High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID).Q24815153
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Missing value estimation methods for DNA microarraysQ28200763
The p47phox mouse knock-out model of chronic granulomatous diseaseQ28504676
Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferatorsQ28512252
Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferationQ32128574
Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytesQ32129114
Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?Q34232437
Cytokines in the liverQ34320108
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptorsQ34339895
Complement and apoptosisQ34353040
PPARalpha agonist-induced rodent tumors: modes of action and human relevanceQ35631058
Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidaseQ35691236
Innate immunity in the liverQ36036373
Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?Q36174039
Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.Q36586072
The clearance of apoptotic cells by complementQ36838417
Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signalingQ38294966
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.Q38336592
Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalateQ38520410
Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitroQ40835154
Peroxisome proliferators activate Kupffer cells in vivoQ42513524
The PPARalpha-leukotriene B4 pathway to inflammation control.Q42552721
Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cellsQ43548374
The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.Q43726411
Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysisQ43838034
The membrane attack complex of complement induces caspase activation and apoptosisQ43900091
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomyQ44185466
Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalateQ44260004
Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligandsQ44398410
Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferatorsQ44761807
The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genesQ45064169
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation propertiesQ45148001
Peroxisome proliferator activated receptor-alpha expression in human liver.Q46493867
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.Q51010973
EDGE: extraction and analysis of differential gene expression.Q51958109
In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.Q52531947
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.Q53411525
Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha.Q53412221
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.Q53439121
Development of hepatocellular carcinomas and increased peroxisomal fatty acid beta-oxidation in rats fed [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643) in the semipurified diet.Q53572901
Effects of peroxisome proliferators on the thymus and spleen of miceQ73223344
Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643Q73248678
In vitro knockout of human p47phox blocks superoxide anion production and LDL oxidation by activated human monocytesQ73520352
Gene expression analysis reveals chemical-specific profilesQ74100166
Pathway studio—the analysis and navigation of molecular networksQ79241603
P433issue3
P304page(s)267-277
P577publication date2007-09-16
P1433published inToxicology and Applied PharmacologyQ2446974
P1476titleTime course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression
P478volume225

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cites work (P2860)
Q35138153A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis
Q37478119Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor
Q42540572Computational toxicology: realizing the promise of the toxicity testing in the 21st century
Q57016009Genes involved in the induction of liver growth by peroxisome proliferators
Q33870766Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages
Q34006474Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells
Q38158164Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.
Q42709872Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved?
Q35210023Peroxisome proliferator-activated receptors and cancer: challenges and opportunities
Q46249387The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions.
Q37125240Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver
Q35633882Toxicogenomic biomarkers for liver toxicity

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