Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology

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Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology is …
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P356DOI10.1104/PP.16.01805
P932PMC publication ID5411137
P698PubMed publication ID28275150

P50authorEugenia RussinovaQ45308143
Wim DejongheQ86624979
P2093author name stringEugenia Russinova
Wim Dejonghe
P2860cites workRapid and orthogonal logic gating with a gibberellin-induced dimerization systemQ24609546
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The chemical compound bubblin induces stomatal mispatterning in Arabidopsis by disrupting the intrinsic polarity of stomatal lineage cellsQ48352337
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Trafficking modulator TENin1 inhibits endocytosis, causes endomembrane protein accumulation at the pre-vacuolar compartment and impairs gravitropic response in Arabidopsis thalianaQ39225910
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High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in ArabidopsisQ42112977
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Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein MutantsQ28552371
Chemical Genetics Uncovers Novel Inhibitors of Lignification, Including p-Iodobenzoic Acid Targeting CINNAMATE-4-HYDROXYLASEQ28597044
Modification of plant cell wall structure accompanied by enhancement of saccharification efficiency using a chemical, lasalocid sodiumQ28822621
The Small Molecule Hyperphyllin Enhances Leaf Formation Rate and Mimics Shoot Meristem Integrity Defects Associated with AMP1 DeficiencyQ28830661
Novel small molecule modulators of plant growth and development identified by high-content screening with plant pollenQ28831335
Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signalingQ28833667
Biomass recalcitrance: engineering plants and enzymes for biofuels productionQ29547628
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteinsQ29616860
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The power of chemical genomics to study the link between endomembrane system components and the gravitropic responseQ30856823
Yucasin is a potent inhibitor of YUCCA, a key enzyme in auxin biosynthesisQ31145029
Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screeningQ33193235
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Chemical interference of pathogen-associated molecular pattern-triggered immune responses in Arabidopsis reveals a potential role for fatty-acid synthase type II complex-derived lipid signalsQ33266497
A high-throughput chemical screen for resistance to Pseudomonas syringae in ArabidopsisQ33318120
Identification of auxins by a chemical genomics approachQ33339296
Endosidin1 defines a compartment involved in endocytosis of the brassinosteroid receptor BRI1 and the auxin transporters PIN2 and AUX1.Q33343419
Identification of IAA transport inhibitors including compounds affecting cellular PIN trafficking by two chemical screening approaches using maize coleoptile systemsQ33354077
Chemical genetic dissection of brassinosteroid-ethylene interactionQ33510298
Identification and preliminary characterization of a new chemical affecting glucosyltransferase activities involved in plant cell wall biosynthesisQ33510301
A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thalianaQ33530168
Identification of an ABCB/P-glycoprotein-specific inhibitor of auxin transport by chemical genomicsQ33578911
A small-molecule screen identifies new functions for the plant hormone strigolactoneQ33684763
A small molecule with differential effects on the PTS1 and PTS2 peroxisome matrix import pathwaysQ33821224
Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway.Q33914738
Clusters of bioactive compounds target dynamic endomembrane networks in vivo.Q34050141
A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in ArabidopsisQ34080446
A chemical biology approach reveals an opposite action between thermospermine and auxin in xylem development in Arabidopsis thalianaQ34161845
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitorsQ34171417
Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.Q34191772
Identification of Novel Inhibitors of 1-Aminocyclopropane-1-carboxylic Acid Synthase by Chemical Screening in Arabidopsis thaliana*Q34236908
Chemical development of intracellular protein heterodimerizersQ34340381
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.Q34355711
Novel plant immune-priming compounds identified via high-throughput chemical screening target salicylic acid glucosyltransferases in ArabidopsisQ34409306
Phenotypic screening in cancer drug discovery - past, present and futureQ34429484
Tracking cancer drugs in living cells by thermal profiling of the proteomeQ34441561
The re-emergence of natural products for drug discovery in the genomics era.Q34459318
Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thalianaQ34464344
Activation of auxin signalling counteracts photorespiratory H2O2-dependent cell death.Q34491416
Chemical genetics to examine cellulose biosynthesisQ34570785
Target identification for small bioactive molecules: finding the needle in the haystackQ34589404
Glutamate signalling via a MEKK1 kinase-dependent pathway induces changes in Arabidopsis root architectureQ34662336
Small molecules for dissecting endomembrane trafficking: a cross-systems view.Q34678179
Molecular locks and keys: the role of small molecules in phytohormone researchQ34722178
Engineering the ABA plant stress pathway for regulation of induced proximityQ35031343
High-throughput screening of small-molecule libraries for inducers of plant defense responsesQ35059275
An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thalianaQ35128870
Unraveling plant hormone signaling through the use of small moleculesQ35225476
Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach.Q35229098
Traffic jams affect plant development and signal transductionQ35709486
Novel Abscisic Acid Antagonists Identified with Chemical Array ScreeningQ35817893
Novel Vein Patterns in Arabidopsis Induced by Small Molecules.Q35843363
The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action MethodsQ35942602
Extending accessible chemical space for the identification of novel leadsQ36068828
Small-molecule antagonists of germination of the parasitic plant Striga hermonthica.Q36080216
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosisQ36459348
New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone deliveryQ36937249
A role for the root cap in root branching revealed by the non-auxin probe naxillinQ37075139
Overexpression of PYL5 in rice enhances drought tolerance, inhibits growth, and modulates gene expressionQ37524633
Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in ArabidopsisQ37570904
Advances in dissecting endomembrane trafficking with small moleculesQ37790139
Small molecules present large opportunities in plant biologyQ37992129
Strategies and future trends to identify the mode of action of phytotoxic compoundsQ38149318
Target identification strategies in plant chemical biologyQ38238085
SIR1, an upstream component in auxin signaling identified by chemical geneticsQ38351967
Multiple Targets for Drug-Induced Mitochondrial ToxicityQ38479531
Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.Q38597939
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectsynthetic biologyQ862838
phenotypeQ104053
P304page(s)5-20
P577publication date2017-03-08
P1433published inPlant PhysiologyQ3906288
P1476titlePlant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology
P478volume174

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cites work (P2860)
Q901400993,4-Dibromo-7-Azaindole Modulates Arabidopsis Circadian Clock by Inhibiting Casein Kinase 1 Activity
Q41048745ATP sensing in living plant cells reveals tissue gradients and stress dynamics of energy physiology.
Q52413089Auxin signaling: a big question to be addressed by small molecules.
Q92479340CHITINASE LIKE1 Regulates Root Development of Dark-Grown Seedlings by Modulating Ethylene Biosynthesis in Arabidopsis thaliana
Q64891787Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.
Q89475682Inhibition of jasmonate-mediated plant defences by the fungal metabolite higginsianin B
Q88661226Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana
Q92353181Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
Q89659406Recent Advances in Plant Chemical Biology of Jasmonates
Q57289130Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches
Q90859997Understanding the language of drugged plants

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