Brain Penetrant LRRK2 Inhibitor

scientific article

Brain Penetrant LRRK2 Inhibitor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ML300123A
P932PMC publication ID3467149
P698PubMed publication ID23066449
P5875ResearchGate publication ID232249941

P50authorDario AlessiQ5222818
Jinwei ZhangQ47825457
Xianming DengQ89024367
Hwan Geun ChoiQ114430558
Matthew P PatricelliQ125308409
Nathanael GrayQ28112823
P2093author name stringZheng Zhao
John M Hatcher
P2860cites workDiscovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.Q46024777
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.Q21135493
Kinase activity of mutant LRRK2 mediates neuronal toxicityQ24303603
The selectivity of protein kinase inhibitors: a further updateQ24654622
Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitorsQ27663972
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control studyQ29614953
Comprehensive analysis of kinase inhibitor selectivityQ29616719
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screeningQ33323340
Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's diseaseQ33812599
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease modelsQ33964804
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's diseaseQ34112588
Role of LRRK2 kinase dysfunction in Parkinson diseaseQ34192817
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.Q35780973
Characterization of TAE684 as a potent LRRK2 kinase inhibitorQ36208468
(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.Q36223954
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questionsQ37225356
LRRK2 and Parkinson diseaseQ37748314
On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studiesQ37856642
Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's diseaseQ38009436
Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.Q40273125
Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neuronsQ43120316
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.Q43501182
P433issue8
P921main subjectHG-10-102-01Q27225603
P304page(s)658-662
P577publication date2012-06-18
P1433published inACS Medicinal Chemistry LettersQ2819061
P1476titleBrain Penetrant LRRK2 Inhibitor
P478volume3

Reverse relations

cites work (P2860)
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Q28551093Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics
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Q48560989LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease
Q38620229LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?
Q28078899LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives
Q54107836LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Q58701452LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
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