A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury

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A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00157.2012
P932PMC publication ID3468496
P698PubMed publication ID22759398
P5875ResearchGate publication ID228114013

P2093author name stringH Thomas Lee
Vivette D D'Agati
Kevin M Brown
Sang Won Park
Mihwa Kim
Ahrom Ham
Joo Yun Kim
P2860cites workSphingosine kinases, sphingosine 1-phosphate, apoptosis and diseasesQ28265044
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The reno-vascular A2B adenosine receptor protects the kidney from ischemiaQ28473410
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigrationQ28592508
Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidneyQ30304269
A(2A) adenosine receptor: a novel therapeutic target in renal diseaseQ30308356
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injuryQ30432124
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injuryQ30439331
Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizonQ30444266
The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteinsQ30465454
Discovery and evaluation of inhibitors of human sphingosine kinaseQ31004970
Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generationQ33808769
Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in miceQ34085244
Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activationQ34430282
Apoptosis and inflammation in renal reperfusion injuryQ34708170
Sphingosine kinases: a novel family of lipid kinasesQ34725633
Recent advances in the pathophysiology of ischemic acute renal failureQ35182393
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.Q36237338
Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation.Q36437881
Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressorQ36446896
Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.Q36569048
Allosteric enhancers for A1 adenosine receptorQ36855834
Differential regulation of sphingosine kinases 1 and 2 in lung injuryQ37162745
Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusionQ37215865
Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injuryQ37217259
A1 adenosine receptor antagonists, agonists, and allosteric enhancersQ37565149
Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate1 receptor activationQ39488891
TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicityQ39738416
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathwaysQ40075805
Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expressionQ40146561
Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptorsQ40740076
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradientQ42026885
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failureQ44185781
Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptorQ44320313
A1adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusionQ44643850
A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in miceQ44705269
A simplified method for HPLC determination of creatinine in mouse serumQ44768327
Constitutive expression of the S1P1 receptor in adult tissues.Q44912029
A rapid radioassay for sphingosine kinaseQ45223032
Perioperative renal protectionQ46583995
Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptorsQ46956798
Hippocampal injury and neurobehavioral deficits are improved by PD 81,723 following hyperglycemic cerebral ischemiaQ48206834
Isoform-selective assays for sphingosine kinase activity.Q51790638
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.Q52551375
Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenesQ68619406
An experimental model for assessment of renal recovery from warm ischemiaQ70248407
PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogsQ71468943
Plasma Creatinine Determination A New and Specific Jaffe Reaction MethodQ72576913
Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptorsQ73532756
Early renal ischemia, with or without reperfusion, activates NFkappaB and increases TNF-alpha bioactivity in the kidneyQ73593555
Neutrophils and acute ischemia-reperfusion injuryQ74741770
Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappaBQ74794442
Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusionQ78253143
Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injuryQ79150887
Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rateQ79408625
Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injuryQ80142589
MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlatesQ80366032
P433issue5
P921main subjectreperfusion injuryQ1413991
P304page(s)F721-32
P577publication date2012-07-03
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleA1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury
P478volume303

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cites work (P2860)
Q52671079A1 -Adenosine receptor activation has biphasic roles in development of acute kidney injury at 4 and 24 h of reperfusion following ischaemia in rats.
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Q89093254Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury
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Q52313686New Paradigms in Adenosine Receptor Pharmacology: Allostery, Oligomerization and Biased Agonism.
Q89839805P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling
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Q30408394The second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancers

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