Low expression of D2R and Wntless correlates with high motivation for heroin

scientific article

Low expression of D2R and Wntless correlates with high motivation for heroin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1037/BNE0000104
P932PMC publication ID4658262
P698PubMed publication ID26501177

P50authorPatricia S GrigsonQ56561934
Robert M. LevensonQ69808974
P2093author name stringArthur Berg
Megan Morse
Andras Hajnal
Danielle N Alexander
Diana M Tacelosky
P2860cites workInteraction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependenceQ24302002
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screensQ24307686
Mu-opioid receptors modulate the stability of dendritic spinesQ24557501
Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in ratsQ27304542
Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behaviorQ28386419
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic developmentQ28571288
Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neuronsQ28576842
Wnt signalling regulates adult hippocampal neurogenesisQ29619688
Cocaine cues drive opposing context-dependent shifts in reward processing and emotional stateQ30500153
Once is too much: conditioned aversion develops immediately and predicts future cocaine self-administration behavior in ratsQ33720901
Alterations in brain structure and functional connectivity in prescription opioid-dependent patientsQ34030705
Transition to addiction is associated with a persistent impairment in synaptic plasticityQ34122596
Reduced striatal dopamine transporters in people with internet addiction disorderQ34268411
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmissionQ34400155
Drug addiction and the memory systems of the brain.Q34875310
Conditioned Aversion for a Cocaine-Predictive Cue is Associated with Cocaine Seeking and Taking in RatsQ35063979
Opiates inhibit neurogenesis in the adult rat hippocampusQ35163722
A history of bingeing on fat enhances cocaine seeking and takingQ35581044
WNTs in the vertebrate nervous system: from patterning to neuronal connectivityQ36098890
Greater avoidance of a heroin-paired taste cue is associated with greater escalation of heroin self-administration in ratsQ36193310
The role of orbitofrontal cortex in drug addiction: a review of preclinical studiesQ36464866
Helping Wingless take flight: how WNT proteins are secretedQ36753332
Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats.Q36880293
Yoked delivery of cocaine is aversive and protects against the motivation for drug in ratsQ37389335
Modulation of opioid receptor function by protein-protein interactionsQ37410471
Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neuronsQ37592198
Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaineQ37626216
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking.Q38421614
Early-onset drug use and risk of later drug problemsQ40966694
Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawalQ41211959
Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neuronsQ41835138
Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaineQ42288838
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.Q42506372
Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection.Q43578207
Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewardsQ43983467
Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.Q44331639
Evidence for addiction-like behavior in the rat.Q45018179
Perseveration in the presence of punishment: the effects of chronic cocaine exposure and lesions to the prefrontal cortexQ45272172
Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats.Q46474451
Behavioral and electrophysiological indices of negative affect predict cocaine self-administrationQ46701217
Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing.Q46846040
Morphine alters the structure of neurons in the nucleus accumbens and neocortex of ratsQ48167146
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.Q48387652
Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine systemQ48415040
Acute effects of cocaine on human brain activity and emotionQ48618466
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor.Q52291688
A rapid method for the regional dissection of the rat brainQ71341046
P4510describes a project that usesImageJQ1659584
P433issue6
P304page(s)744-755
P577publication date2015-10-26
P1433published inBehavioral NeuroscienceQ4880707
P1476titleLow expression of D2R and Wntless correlates with high motivation for heroin
P478volume129

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cites work (P2860)
Q88964202Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry
Q50270226DRD2 and ANKK1 genes associate with late-onset heroin dependence in men.
Q37308012Early avoidance of a heroin-paired taste-cue and subsequent addiction-like behavior in rats.
Q36193310Greater avoidance of a heroin-paired taste cue is associated with greater escalation of heroin self-administration in rats
Q38568452Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N-Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality.
Q38653277Identifying novel members of the Wntless interactome through genetic and candidate gene approaches.
Q38807377Preweaning iron deficiency increases non-contingent responding during cocaine self-administration in rats.

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