Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells

scientific article

Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2012-02-410712
P932PMC publication ID3471518
P698PubMed publication ID22872685
P5875ResearchGate publication ID230633167

P50authorJohn MascarenhasQ60320904
Joseph TripodiQ60320908
P2093author name stringXiaoli Wang
Yan Li
Min Lu
Ronald Hoffman
Vesna Najfeld
Marina Kremyanskaya
Goar Mosoyan
P2860cites workCytogenetic conversion in a case of polycythaemia vera treated with interferon-alphaQ72490598
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Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domainsQ27654637
High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2aQ27824871
CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patientsQ28238474
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Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosisQ33391880
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Interferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms.Q37289795
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p53 in chronic myelogenous leukemia in acute phaseQ37550931
JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasmsQ39501601
A Small-Molecule Inhibitor of MDMX Activates p53 and Induces ApoptosisQ39632042
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosisQ39634508
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Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agentsQ40054238
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.Q41199732
STAT-1 interacts with p53 to enhance DNA damage-induced apoptosisQ42452343
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitorQ46713383
MDM2 and MDMX in cancer and development.Q51889545
N-ras and p53 gene mutations in Japanese patients with myeloproliferative disorders.Q52547649
Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells.Q54594373
Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera.Q54598140
Clinical-scale cultures of cord blood CD34(+) cells to amplify committed progenitors and maintain stem cell activity.Q54615281
Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia veraQ58416020
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectpolycythemia veraQ948318
P1104number of pages8
P304page(s)3098-3105
P577publication date2012-08-07
P1433published inBloodQ885070
P1476titleCombination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells
P478volume120

Reverse relations

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