ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration

scientific article

ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/ABBS/GMV101
P932PMC publication ID4659443
P698PubMed publication ID26474739

P2093author name stringQin Li
Jia Chen
Ying Xiong
Catherine C Y Chang
Ming Zhu
Xiaowei Zhang
Baoliang Song
Boliang Li
Dongqing Guo
Guangjing Hu
Jiajia Xu
Tayuan Chang
Xiaonan Zhao
P2860cites workKnockdown of ACAT-1 reduces amyloidogenic processing of APPQ24301804
Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasoneQ24302908
Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophagesQ24310188
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cellsQ24318507
RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoformQ24601853
Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiaeQ27931537
Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestineQ28137924
Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomesQ28140941
Alzheimer's disease: the cholesterol connectionQ28186482
Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2Q28189085
Acyl-coenzyme A:cholesterol acyltransferaseQ28245277
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophagesQ28252737
Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminusQ28277913
Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein αQ28288583
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extensionQ28513050
THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMQ29391553
BACE1: the beta-secretase enzyme in Alzheimer's diseaseQ33202614
Cell cholesterol efflux: integration of old and new observations provides new insights.Q33605655
Intracellular cholesterol trafficking: role of the NPC1 proteinQ33944786
ACAT inhibition and amyloid beta reductionQ34052308
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease processQ34110227
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.Q34651211
Cholesterol and the biology of Alzheimer's disease.Q35625391
Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosisQ36414556
Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance geneQ37064656
Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's diseaseQ37073099
ACAT as a drug target for Alzheimer's diseaseQ37103056
Acyl-coenzyme A:cholesterol acyltransferasesQ37264194
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathwayQ37415858
Intracellular cholesterol homeostasis and amyloid precursor protein processingQ37715386
Cellular membrane fluidity in amyloid precursor protein processing.Q38189670
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease.Q38212139
MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formationQ39096724
Ghrelin inhibits foam cell formation via simultaneously down-regulating the expression of acyl-coenzyme A:cholesterol acyltransferase 1 and up-regulating adenosine triphosphate-binding cassette transporter A1.Q39800594
Human ACAT1 gene expression and its involvement in the development of atherosclerosisQ40361549
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptideQ40777105
Synergistic transcriptional activation of human Acyl-coenzyme A: cholesterol acyltransterase-1 gene by interferon-gamma and all-trans-retinoic acid THP-1 cellsQ40799447
Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cellsQ40939308
Cholesterol modulates alpha-secretase cleavage of amyloid precursor proteinQ41226800
Secreted forms of beta-amyloid precursor protein protect against ischemic brain injuryQ41451125
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
The survival of rat cerebral cortical neurons in the presence of trophic APP peptidesQ48129570
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor proteinQ48342880
Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in ratsQ48541352
Analysis of the distribution of cholesterol in the intact cellQ50169842
The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay.Q51782635
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.Q52086849
Human Acyl-CoA:Cholesterol Acyltransferase-1 Is a Homotetrameric Enzyme in Intact Cells andin VitroQ61898959
Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblastsQ68727843
19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cellsQ70193016
Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestinesQ77150716
U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cellsQ78109239
P433issue12
P304page(s)951-959
P577publication date2015-10-15
P1433published inActa Biochimica et Biophysica SinicaQ2183997
P1476titleACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration
P478volume47

Reverse relations

cites work (P2860)
Q39180626Cellular Cholesterol Homeostasis in Alzheimer's Disease
Q45305840Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Q38735980Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors
Q50299793SOAT1,2 transfer acyl group to CHOL forming CHEST
Q38735984The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters

Search more.