Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo

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Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0172928
P932PMC publication ID5365107
P698PubMed publication ID28339457

P50authorArkasubhra GhoshQ39186591
P2093author name stringAjay Sharma
Rajiv R Mohan
Elizabeth A Giuliano
Suneel Gupta
Jason T Rodier
Nathan P Hesemann
Prashant R Sinha
P2860cites workmiR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathyQ24298641
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationQ24302554
Progress in corneal wound healingQ28081311
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013Q28083357
Smad regulation in TGF-beta signal transductionQ28215642
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signallingQ28251743
Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heartQ28581449
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
Gene therapy in the cornea: 2005--presentQ30459643
BMP7 gene transfer via gold nanoparticles into stroma inhibits corneal fibrosis in vivoQ31120997
Gene therapy in the corneaQ33217113
Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapyQ33386030
Trichostatin a inhibits corneal haze in vitro and in vivoQ33402864
Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblastsQ33624247
Growth factors: importance in wound healing and maintenance of transparency of the corneaQ33805838
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in miceQ33853415
Efficacious and safe tissue-selective controlled gene therapy approaches for the corneaQ33886878
Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivoQ34062422
AAV serotype influences gene transfer in corneal stroma in vivo.Q34079531
Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeysQ34559912
Role of transforming growth factor Beta in corneal function, biology and pathologyQ34623130
Graft rejection rate and graft failure rate of penetrating keratoplasty (PKP) vs lamellar procedures: a systematic reviewQ35185283
Significant inhibition of corneal scarring in vivo with tissue-selective, targeted AAV5 decorin gene therapyQ35220955
Corneal Haze Following Refractive Surgery: A Review of Pathophysiology, Incidence, Prevention, and Treatment.Q35944419
Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis InhibitionQ36000612
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosisQ36371664
Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad SignalingQ36419275
ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosisQ36569602
Versatility of AAV vectors for retinal gene transferQ36965152
Characterization of Inhibitor of differentiation (Id) proteins in human cornea.Q36971447
Transforming Growth Factor β Signal Transduction: A Potential Target for Maintenance/Restoration of Transparency of the CorneaQ37786166
AAV-Mediated Gene Therapy for Research and Therapeutic PurposesQ38766616
Structural Basis of Intracellular TGF-β Signaling: Receptors and SmadsQ38934096
Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse modelQ40132971
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectorsQ40692830
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activationQ40728276
TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylationQ43128396
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium.Q43230127
Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitroQ44327668
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in ratsQ44507331
Ultrapure chitosan oligomers as carriers for corneal gene transferQ44535494
Gene transfer into rabbit keratocytes using AAV and lipid-mediated plasmid DNA vectors with a lamellar flap for stromal access.Q45858525
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO modelQ45862411
Canine corneal fibroblast and myofibroblast transduction with AAV5.Q45875695
Rapid ocular angiogenic control via naked DNA delivery to corneaQ45878926
Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7.Q46241531
Causes and prevalence of visual impairment among adults in the United StatesQ46890945
Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assemblyQ78106447
Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysisQ81251018
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectgene therapyQ213901
P304page(s)e0172928
P577publication date2017-03-24
P1433published inPLOS OneQ564954
P1476titleTargeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo
P478volume12