Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans

scientific article

Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1590/1414-431X20154732
P932PMC publication ID4661021
P698PubMed publication ID26445237

P50authorSalvador Said-FernándezQ40131467
Mario Simental-MendíaQ57057224
P2093author name stringA Soto-Domínguez
E Álvarez-Lozano
G R Padilla-Rivas
H G Martínez-Rodríguez
J Lara-Arias
P2860cites workHigh-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cellsQ24548319
Normal bone anatomy and physiologyQ28299969
Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytesQ30695640
Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatment optionsQ36035182
Gene therapy: the good, the bad, and the uglyQ36108635
The control of chondrogenesisQ36282196
Emerging technologies and fourth generation issues in cartilage repairQ37326362
Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantationQ37338012
Unraveling the transcriptional regulatory machinery in chondrogenesisQ37877164
The response of articular cartilage to mechanical injuryQ40102646
Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathwaysQ40432068
Bioreactor-Induced Chondrocyte Maturation Is Dependent on Cell Passage and Onset of LoadingQ40840856
Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivoQ42826063
IGF-1 gene therapy to protect articular cartilage in a rat model of joint damage.Q43617332
Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery systemQ44036702
The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytesQ44541021
Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transferQ44606527
Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.Q44777062
Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivoQ45332098
Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantationQ45880338
Application of tissue-engineered cartilage with BMP-7 gene to repair knee joint cartilage injury in rabbitsQ45889212
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcriptionQ46629634
The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee.Q51296464
Regulation of chondrogenesis by transforming growth factor-beta 3 and insulin-like growth factor-1 from human mesenchymal umbilical cord blood cellsQ84230830
Effects of Low Concentrated BMP-7 Administered by co-Cultivation or Plasmid Transfection on Human Osteoarthritic ChondrocytesQ84613248
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1063-1070
P577publication date2015-10-06
P1433published inBrazilian Journal of Medical and Biological ResearchQ2025772
P1476titleCotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans
P478volume48

Reverse relations

cites work (P2860)
Q92839986Association of insulin-like growth factor I gene polymorphisms with the risk of osteoporosis in a Chinese population
Q33754990Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway
Q64083778Interleukin-1 receptor antagonist protein (IL-1Ra) and miR-140 overexpression via pNNS-conjugated chitosan-mediated gene transfer enhances the repair of full-thickness cartilage defects in a rabbit model
Q64064105NNS-Conjugated Chitosan Mediated IGF-1 and miR-140 Overexpression in Articular Chondrocytes Improves Cartilage Repair

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