Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity.

scientific article

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PBIO.2000698
P932PMC publication ID5370089
P698PubMed publication ID28350803

P50authorGareth WilliamsQ56948825
Benedikt BerningerQ57413163
Claudio CantùQ59506028
Andrea RiveraQ86792137
Kasum AzimQ87688073
Olivier RaineteauQ55098243
Arthur ButtQ43108370
P2093author name stringGuillaume Marcy
Vanessa Donega
Francesca Pieropan
Diane Angonin
P2860cites workInteraction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathwaysQ24317627
Mosaic Subventricular Origins of Forebrain OligodendrogenesisQ26752420
Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesisQ26820687
New neurons in the adult striatum: from rodents to humansQ28080805
Characterization of the subventricular zone of the adult human brain: evidence for the involvement of Bcl-2Q28143927
Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal miceQ28273410
Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylationQ28574037
Dixdc1 is a critical regulator of DISC1 and embryonic cortical developmentQ28588322
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and functionQ29547320
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseQ29547614
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumorsQ29619814
Targeted electroporation of defined lateral ventricular walls: a novel and rapid method to study fate specification during postnatal forebrain neurogenesisQ30500320
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.Q30513975
GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivoQ58456357
Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survivalQ71394433
Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiationQ75447880
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid modelQ43284375
Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death.Q44340326
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.Q44770129
Cortical neurogenesis enhanced by chronic perinatal hypoxiaQ46509953
Mosaic organization of neural stem cells in the adult brainQ46817366
Notch receptor activation inhibits oligodendrocyte differentiationQ47713081
Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone.Q48253462
Intraventricular injection of FGF-2 promotes generation of oligodendrocyte-lineage cells in the postnatal and adult forebrainQ48387856
Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state.Q48561316
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neuronsQ50463142
GSK3β regulates oligodendrogenesis in the dorsal microdomain of the subventricular zone via Wnt-β-catenin signaling.Q54364118
Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screeningQ33569550
Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis.Q33747754
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during agingQ33808257
Intranasal epidermal growth factor treatment rescues neonatal brain injuryQ33931902
Tissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studiesQ34006509
Transient muscarinic and glutamatergic stimulation of neural stem cells triggers acute and persistent changes in differentiationQ34122870
A searchable cross-platform gene expression database reveals connections between drug treatments and diseaseQ34123013
Immune system modulates the function of adult neural stem cells.Q34244910
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signallingQ34342952
Neurogenesis in the striatum of the adult human brainQ34406106
3-dimensional examination of the adult mouse subventricular zone reveals lineage-specific microdomainsQ34482047
Origin of oligodendrocytes in the subventricular zone of the adult brain.Q34551388
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury.Q34672009
Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylasesQ34699724
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.Q34734393
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous systemQ34825266
Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injuryQ35125538
Negative regulation of Yap during neuronal differentiationQ35605297
Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiationQ35693398
RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.Q35816498
Spatiotemporal changes to the subventricular zone stem cell pool through agingQ35986952
The distinct temporal origins of olfactory bulb interneuron subtypesQ36826632
Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brainQ36883223
Activation of subventricular zone stem cells after neuronal injury.Q36908499
The effect of neurodegenerative diseases on the subventricular zone.Q36912768
A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor propertiesQ36997095
Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11.Q37497085
Restrictions in time and space--new insights into generation of specific neuronal subtypes in the adult mammalian brainQ37852096
Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from hereQ38114939
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades LaterQ38597817
Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brainQ39445832
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cellsQ39812717
The aging neurogenic subventricular zone.Q42493596
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSubventricular zoneQ937403
pharmacogenomicsQ1152227
P304page(s)e2000698
P577publication date2017-03-28
P1433published inPLOS BiologyQ1771695
P1476titlePharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity
P478volume15

Reverse relations

cites work (P2860)
Q36371993A question of fate.
Q91816272Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?
Q93063652Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium
Q58805417Drug repurposing for neuroregeneration in multiple sclerosis
Q52316006From gene networks to drugs: systems pharmacology approaches for AUD.
Q92229243Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse
Q89236099Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A
Q39335649Heterogeneous populations of neural stem cells contribute to myelin repair.
Q92964548Insights into ligand expression heterogeneity across multiple cell types in the adult forebrain that regulates neural stem cell behavior
Q54945989Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.