Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury

scientific article

Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/TX300172S
P932PMC publication ID3475366
P698PubMed publication ID22793666
P5875ResearchGate publication ID229089404

P2093author name stringYan Li
Maria Novalen
Jack Uetrecht
M Anthony Hayes
Amy M Sharma
P2860cites workMetabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.Q30010977
Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometriesQ33574656
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavirQ34117815
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicityQ35623893
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Mechanisms of drug-induced liver injury.Q36439183
PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonideQ39896398
Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.Q40562633
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.Q42274626
Serious adverse cutaneous and hepatic toxicities associated with nevirapine use by non-HIV-infected individualsQ44727378
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Animal models of idiosyncratic drug reactions.Q45135908
Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infectionQ45751686
Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes.Q45979562
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.Q46409516
Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.Q46854731
Case-control exploration of relationships between early rash or liver toxicity and plasma concentrations of nevirapine and primary metabolitesQ46879492
Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1.Q52239994
Over-expression of CYP2C11, the major male-specific form of hepatic cytochrome P450, in the presence of nominal pulses of circulating growth hormone in adult male rats neonatally exposed to low levels of monosodium glutamateQ72818479
Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomesQ74094977
P433issue8
P921main subjectnevirapineQ263713
P304page(s)1708-1719
P577publication date2012-07-26
P1433published inChemical Research in ToxicologyQ473530
P1476titleBioactivation of nevirapine to a reactive quinone methide: implications for liver injury
P478volume25

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cites work (P2860)
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Q26824391Idiosyncratic adverse drug reactions: current concepts
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Q36843910Nevirapine inhibits the anti-HIV activity of CD8+ cells
Q34794696Proteomic analysis of serum and urine of HIV-monoinfected and HIV/HCV-coinfected patients undergoing long term treatment with nevirapine.
Q34378297Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?

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