p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

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p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0175121
P932PMC publication ID5378409
P698PubMed publication ID28369097

P2093author name stringMing Zhao
Xiaohe Yang
Zhiying Guo
Amanda B Parris
Erin W Howard
P2860cites workA comparison of gene expression signatures from breast tumors and breast tissue derived cell linesQ21343013
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ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Moderate alcohol intake and cancer incidence in womenQ28236401
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012Q28263109
p21 is necessary for the p53-mediated G1 arrest in human cancer cellsQ28291118
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer CellsQ28383151
ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasisQ28384120
Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer preventionQ28708831
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Evaluation of Acute Alcohol Intoxication as the Primary Cause of Death: A Diagnostic Challenge for Forensic Pathologists.Q53549899
Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholicsQ57009140
Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancerQ73923025
Twenty-year follow-up of the Royal Marsden randomized, double-blinded tamoxifen breast cancer prevention trialQ79803594
Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the diseaseQ30747351
In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cellsQ33910831
Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunctionQ34293764
Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumorsQ34302077
Alcohol consumption and breast cancer recurrence and survival among women with early-stage breast cancer: the life after cancer epidemiology studyQ34334908
p53 inactivation upregulates p73 expression through E2F-1 mediated transcriptionQ34405292
MCF-7: the first hormone-responsive breast cancer cell lineQ34434141
p53: good cop/bad cop.Q34768712
Alcohol consumption in relation to aberrant DNA methylation in breast tumorsQ35109249
Alcohol metabolism in human cells causes DNA damage and activates the Fanconi anemia-breast cancer susceptibility (FA-BRCA) DNA damage response networkQ35566416
Moderate alcohol consumption during adult life, drinking patterns, and breast cancer riskQ35797100
Deciphering the BRCA1 Tumor Suppressor NetworkQ35859458
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ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cellsQ36499775
The role of BRCA1 in transcriptional regulation and cell cycle controlQ36602565
Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the JapaneseQ36620938
Coping with stress: multiple ways to activate p53.Q36745375
Gamma-H2AX - a novel biomarker for DNA double-strand breaks.Q37210367
Association between Mutation and Expression of TP53 as a Potential Prognostic Marker of Triple-Negative Breast CancerQ37367403
Cytokine Changes following Acute Ethanol Intoxication in Healthy Men: A Crossover StudyQ37549546
Formation of acetaldehyde-derived DNA adducts due to alcohol exposureQ37784862
Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.Q38363282
Diet and alcohol consumption in relation to p53 mutations in breast tumorsQ38449160
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cellsQ38847887
Molecular Screening for P53 Mutations among Tobacco Smokers in a Survey of Awareness of Links between Tobacco, Alcohol Use and Cancer in Saudi ArabiaQ40378785
Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice.Q40496832
Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell lineQ40607298
Implication of p53 in base excision DNA repair: in vivo evidenceQ40750276
DNA damage, DNA repair, and alcohol toxicity--a reviewQ41601168
Do pre-diagnostic drinking habits influence breast cancer survival?Q43643652
Association between p53 gene mutations and tobacco and alcohol exposure in laryngeal squamous cell carcinoma.Q44801313
Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens.Q45064489
Alcohol promotes migration and invasion of triple-negative breast cancer cells through activation of p38 MAPK and JNK.Q46500752
Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: potential factors involved in alcohol drinking promotion of breast cancerQ46867564
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)e0175121
P577publication date2017-04-03
P1433published inPLOS OneQ564954
P1476titlep53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells
P478volume12

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cites work (P2860)
Q414210312,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells
Q52683601Low concentrations of ethanol during irradiation drastically reduce DNA damage caused by very high doses of ionizing radiation.
Q47237041The protective effect of PFTα on alcohol-induced osteonecrosis of the femoral head

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