Anti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins.

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Anti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP17944
P932PMC publication ID4668579
P698PubMed publication ID26632347
P5875ResearchGate publication ID285657929

P50authorAnja KovandaQ52721573
Matja ZalarQ57666134
P2093author name stringJanez Plavec
Boris Rogelj
Primož Šket
P2860cites workTMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteinsQ41969994
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexesQ42424866
A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acidsQ43883562
Characterization of DNA G-quadruplex species forming from C9ORF72 G4C2-expanded repeats associated with amyotrophic lateral sclerosis and frontotemporal lobar degenerationQ46808003
Hydration regulates thermodynamics of G-quadruplex formation under molecular crowding conditions.Q51181744
The effect of molecular crowding on the stability of human c-MYC promoter sequence I-motif at neutral pH.Q54745909
Fundamental aspects of the nucleic acid i-motif structuresQ58621192
C9ORF72 hexanucleotide expansions of 20-22 repeats are associated with frontotemporal deteriorationQ63315204
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTDQ24634583
Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from the intron of the N-myc geneQ27677027
Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loopsQ27678724
A tetrameric DNA structure with protonated cytosine.cytosine base pairsQ27732034
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.Q33715387
Making sense of G‐quadruplex and i‐motif functions in oncogene promotersQ34271763
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.Q34326849
The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elementsQ35126113
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cellsQ35695216
The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founderQ36466470
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.Q36666933
The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structuresQ36742244
A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeatsQ36801066
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regionsQ36978525
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteinsQ37094833
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degenerationQ37340843
A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR.Q37358864
Circular dichroism and conformational polymorphism of DNA.Q37384531
Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort studyQ37429235
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding patternQ37455886
The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structureQ37701666
Circular dichroism spectroscopy of DNA: from duplexes to quadruplexesQ38018574
Unconventional features of C9ORF72 expanded repeat in amyotrophic lateral sclerosis and frontotemporal lobar degenerationQ38212431
i-Motif DNA: structure, stability and targeting with ligands.Q38222630
Molecular mechanisms in DM1 - a focus on foci.Q38326275
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)17944
P577publication date2015-12-03
P1433published inScientific ReportsQ2261792
P1476titleAnti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins
P478volume5

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cites work (P2860)
Q55326506(C2G4)n repeat expansion sequences from the C9orf72 gene form an unusual DNA higher-order structure in the pH range of 5-6.
Q58109729C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies
Q64948055C9orf72-mediated ALS and FTD: multiple pathways to disease.
Q92880997Chasing Particularities of Guanine- and Cytosine-Rich DNA Strands
Q64999273Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds.
Q52721505Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls.
Q89863711Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease
Q40950497Human DDX21 binds and unwinds RNA guanine quadruplexes.
Q61816243Molecular Mechanisms of Neurodegeneration Related to Hexanucleotide Repeat Expansion
Q57049075NMR structure of a G-quadruplex formed by four d(G4C2) repeats: insights into structural polymorphism
Q90382816Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction
Q89701717Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications
Q39458329RNA Misprocessing in C9orf72-Linked Neurodegeneration
Q48277735Stabilization of Telomeric I-Motif Structures by (2'S)-2'-Deoxy-2'-C-Methylcytidine Residues
Q93006570Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Q48176921Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.
Q33720889Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions.
Q90021829The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules
Q61800810pH-driven conformational switch between non-canonical DNA structures in a C-rich domain of EGFR promoter

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