Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

scientific article

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/BRAIN/AWV289
P932PMC publication ID4668920
P698PubMed publication ID26463675
P5875ResearchGate publication ID282873514

P50authorMercedes RicoteQ54165693
Vanessa NuñezQ56992816
Alerie Guzman de la FuenteQ59163306
Robin FranklinQ61479232
P2093author name stringEimear Linehan
Tianxia Wu
Kory R Johnson
Denise C Fitzgerald
Bibiana Bielekova
Muktha S Natrajan
Abbe H Crawford
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9-cis retinoic acid is a high affinity ligand for the retinoid X receptorQ28119031
Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cellsQ28258492
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiationQ28290361
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signallingQ28308310
Characterization of three RXR genes that mediate the action of 9-cis retinoic acidQ28343068
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceQ29614354
Fate mapping analysis reveals that adult microglia derive from primitive macrophagesQ29616177
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Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiencyQ30052479
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Differential roles of microglia and monocytes in the inflamed central nervous systemQ30585165
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodelingQ30619787
The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.Q43940143
Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expressionQ45223348
Remyelination capacity of the MS brain decreases with disease chronicityQ45353313
Crosstalk between RXR, LXR and VDR within blood mononuclear cellular model.Q45936281
Identification of a microglia phenotype supportive of remyelinationQ46582759
Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.Q46736235
Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosusQ47849248
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.Q47954187
Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelinationQ48104659
Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.Q52086067
Expansion and preferential activation of the CD14(+)CD16(+) monocyte subset during multiple sclerosis.Q53099338
Aging is associated with a shift of fatty metabolism toward lipogenesis.Q54354425
Inhibition of CNS remyelination by the presence of semaphorin 3A.Q54383932
Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients.Q54524078
Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelinationQ73320779
From the Food and Drug AdministrationQ73513367
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimersQ74253388
Decline in rate of colonization of oligodendrocyte progenitor cell (OPC)-depleted tissue by adult OPCs with ageQ79132686
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migrationQ86492751
Inefficient clearance of myelin debris by microglia impairs remyelinating processesQ30636334
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imagingQ30835804
Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damageQ31061626
Retinoid X receptor gamma signaling accelerates CNS remyelinationQ33580095
Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiencyQ33683897
The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.Q33917441
Intranasal epidermal growth factor treatment rescues neonatal brain injuryQ33931902
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.Q33935023
RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivoQ34052386
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosisQ34109903
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.Q34377321
Myelin-derived lipids modulate macrophage activity by liver X receptor activationQ34416303
BexaroteneQ34434077
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cellsQ34602983
Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissueQ35612964
Epigenetic regulation by RARα maintains ligand-independent transcriptional activityQ35633556
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged miceQ35785441
Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.Q35837349
Mechanism of the nuclear receptor molecular switchQ35846738
A role for TGF-beta in oligodendrocyte differentiationQ36232939
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation statusQ36722852
Rejuvenation of regeneration in the aging central nervous systemQ37023170
Debris clearance by microglia: an essential link between degeneration and regeneration.Q37092476
Astrocyte-derived endothelin-1 inhibits remyelination through notch activationQ37604029
Vitamin D as an early predictor of multiple sclerosis activity and progressionQ37723877
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cellsQ37736265
Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors.Q37775129
Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune responseQ38005670
Immune surveillance in the central nervous systemQ38029971
Retinoid X receptors in macrophage biology.Q38108904
The translational biology of remyelination: past, present, and futureQ38180416
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammationQ39342489
Aging enhances classical activation but mitigates alternative activation in the central nervous systemQ40644711
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shockQ41808787
Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosisQ43145317
P4510describes a project that usesImageJQ1659584
P433issuePt 12
P407language of work or nameEnglishQ1860
P921main subjectphagocytosisQ184726
P304page(s)3581-3597
P577publication date2015-10-12
P1433published inBrainQ897386
P1476titleRetinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination
P478volume138

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