scholarly article | Q13442814 |
P50 | author | Mercedes Ricote | Q54165693 |
Vanessa Nuñez | Q56992816 | ||
Alerie Guzman de la Fuente | Q59163306 | ||
Robin Franklin | Q61479232 | ||
P2093 | author name string | Eimear Linehan | |
Tianxia Wu | |||
Kory R Johnson | |||
Denise C Fitzgerald | |||
Bibiana Bielekova | |||
Muktha S Natrajan | |||
Abbe H Crawford | |||
P2860 | cites work | PPAR-gamma: Therapeutic Potential for Multiple Sclerosis | Q21342822 |
Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition | Q24310738 | ||
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models | Q24628845 | ||
Nuclear Receptors, RXR, and the Big Bang | Q26821789 | ||
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor | Q28119031 | ||
Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells | Q28258492 | ||
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation | Q28290361 | ||
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling | Q28308310 | ||
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid | Q28343068 | ||
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance | Q29614354 | ||
Fate mapping analysis reveals that adult microglia derive from primitive macrophages | Q29616177 | ||
Remyelination in the CNS: from biology to therapy | Q30040587 | ||
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency | Q30052479 | ||
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. | Q30559101 | ||
Differential roles of microglia and monocytes in the inflamed central nervous system | Q30585165 | ||
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling | Q30619787 | ||
The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. | Q43940143 | ||
Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression | Q45223348 | ||
Remyelination capacity of the MS brain decreases with disease chronicity | Q45353313 | ||
Crosstalk between RXR, LXR and VDR within blood mononuclear cellular model. | Q45936281 | ||
Identification of a microglia phenotype supportive of remyelination | Q46582759 | ||
Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. | Q46736235 | ||
Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus | Q47849248 | ||
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. | Q47954187 | ||
Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination | Q48104659 | ||
Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. | Q52086067 | ||
Expansion and preferential activation of the CD14(+)CD16(+) monocyte subset during multiple sclerosis. | Q53099338 | ||
Aging is associated with a shift of fatty metabolism toward lipogenesis. | Q54354425 | ||
Inhibition of CNS remyelination by the presence of semaphorin 3A. | Q54383932 | ||
Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients. | Q54524078 | ||
Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination | Q73320779 | ||
From the Food and Drug Administration | Q73513367 | ||
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers | Q74253388 | ||
Decline in rate of colonization of oligodendrocyte progenitor cell (OPC)-depleted tissue by adult OPCs with age | Q79132686 | ||
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration | Q86492751 | ||
Inefficient clearance of myelin debris by microglia impairs remyelinating processes | Q30636334 | ||
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging | Q30835804 | ||
Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage | Q31061626 | ||
Retinoid X receptor gamma signaling accelerates CNS remyelination | Q33580095 | ||
Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency | Q33683897 | ||
The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages. | Q33917441 | ||
Intranasal epidermal growth factor treatment rescues neonatal brain injury | Q33931902 | ||
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. | Q33935023 | ||
RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo | Q34052386 | ||
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis | Q34109903 | ||
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. | Q34377321 | ||
Myelin-derived lipids modulate macrophage activity by liver X receptor activation | Q34416303 | ||
Bexarotene | Q34434077 | ||
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells | Q34602983 | ||
Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue | Q35612964 | ||
Epigenetic regulation by RARα maintains ligand-independent transcriptional activity | Q35633556 | ||
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice | Q35785441 | ||
Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. | Q35837349 | ||
Mechanism of the nuclear receptor molecular switch | Q35846738 | ||
A role for TGF-beta in oligodendrocyte differentiation | Q36232939 | ||
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status | Q36722852 | ||
Rejuvenation of regeneration in the aging central nervous system | Q37023170 | ||
Debris clearance by microglia: an essential link between degeneration and regeneration. | Q37092476 | ||
Astrocyte-derived endothelin-1 inhibits remyelination through notch activation | Q37604029 | ||
Vitamin D as an early predictor of multiple sclerosis activity and progression | Q37723877 | ||
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells | Q37736265 | ||
Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors. | Q37775129 | ||
Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response | Q38005670 | ||
Immune surveillance in the central nervous system | Q38029971 | ||
Retinoid X receptors in macrophage biology. | Q38108904 | ||
The translational biology of remyelination: past, present, and future | Q38180416 | ||
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation | Q39342489 | ||
Aging enhances classical activation but mitigates alternative activation in the central nervous system | Q40644711 | ||
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock | Q41808787 | ||
Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis | Q43145317 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P433 | issue | Pt 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | phagocytosis | Q184726 |
P304 | page(s) | 3581-3597 | |
P577 | publication date | 2015-10-12 | |
P1433 | published in | Brain | Q897386 |
P1476 | title | Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination | |
P478 | volume | 138 |
Q57179000 | A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics |
Q47835493 | Achievements and obstacles of remyelinating therapies in multiple sclerosis. |
Q38870619 | Activation of FXR pathway does not alter glial cell function |
Q64120075 | Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats |
Q92131927 | Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions |
Q26747242 | CNS Remyelination and the Innate Immune System |
Q90732168 | Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells |
Q47276728 | Clinical implications of myelin regeneration in the central nervous system |
Q47549630 | Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Ageing Mice Visualized by Ex Vivo Live Multiphoton Imaging. |
Q39375830 | Drug discovery for remyelination and treatment of MS. |
Q38934165 | E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord |
Q93042489 | Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury |
Q38749164 | Immunosenescence of microglia and macrophages: impact on the ageing central nervous system. |
Q92806880 | Inhibitory milieu at the multiple sclerosis lesion site and the challenges for remyelination |
Q98290075 | Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD |
Q89746267 | Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury |
Q26765298 | Macrophage polarization in nerve injury: do Schwann cells play a role? |
Q48001723 | Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy |
Q90484137 | Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells |
Q55122769 | Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. |
Q38916635 | Microglia and Monocyte-Derived Macrophages in Stroke |
Q44159046 | Network-Based Method for Identifying Co- Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues. |
Q37644290 | Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. |
Q89586468 | Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system |
Q36410286 | Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes. |
Q36774123 | RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers. |
Q37376545 | Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells |
Q49986398 | Regenerating CNS myelin - from mechanisms to experimental medicines. |
Q36380800 | Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber |
Q26744475 | Regenerative Capacity of Macrophages for Remyelination |
Q39420410 | Remyelination therapies: a new direction and challenge in multiple sclerosis |
Q38814687 | Remyelination: A Potential Therapeutic Strategy for Alzheimer's Disease? |
Q58789337 | Retinoid X Receptor Antagonists |
Q58721330 | Targeting senescence to delay progression of multiple sclerosis |
Q91744941 | The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System |
Q61805706 | The cell type resolved mouse transcriptome in neuron-enriched brain tissues from the hippocampus and cerebellum during prion disease |
Q90288376 | The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke |
Q59339809 | The physiology of foamy phagocytes in multiple sclerosis |
Q93132600 | The pro-remyelination properties of microglia in the central nervous system |
Q92300904 | Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors |
Q90573280 | White Matter Stroke Induces a Unique Oligo-Astrocyte Niche That Inhibits Recovery |
Q92859878 | pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis |
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