Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

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Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.375881
P932PMC publication ID3481327
P698PubMed publication ID22955282

P2093author name stringAmin Afrazi
Charlotte E Egan
Matthew D Neal
David J Hackam
Chhinder P Sodhi
Mitchell Dyer
Misty Good
Congrong Ma
Ibrahim Yazji
John Ozolek
Hongpeng Jia
Thomas Prindle
Maria F Branca
Ryan Marino
Dennis Slagle
Zachary Grant
P2860cites workDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingQ24310750
JNK signalling modulates intestinal homeostasis and tumourigenesis in miceQ41895017
Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factorsQ43225631
Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferationQ45097924
EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture.Q51901843
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.Q53526875
Necrotizing enterocolitisQ83236511
Intestinal stem cellsQ84015538
LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingQ24606839
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndromeQ24627524
Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitisQ24629285
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusionQ24681282
Identification of stem cells in small intestine and colon by marker gene Lgr5Q28131701
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxaQ28204059
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Efficient in vivo manipulation of mouse genomic sequences at the zygote stageQ29547306
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell nicheQ30495954
The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitisQ33254555
Interactions between the host innate immune system and microbes in inflammatory bowel diseaseQ33554402
Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitisQ33618589
Intestinal stem cells and their roles during mucosal injury and repairQ33692786
Expansion of intestinal epithelial stem cells during murine developmentQ34079249
Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epitheliumQ34091864
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensableQ34217232
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populationsQ34242246
Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitisQ34360448
Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cellsQ34699713
Bmi1 is expressed in vivo in intestinal stem cellsQ34785173
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.Q34876574
New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyondQ35073720
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.Q35122385
Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancerQ35763252
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cellsQ35845010
Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.Q35903227
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.Q36094184
p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitisQ37078139
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitisQ37142110
Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of miceQ37337711
Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in DrosophilaQ37379590
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complexQ39613141
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrierQ40313125
Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitriteQ40400544
Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitutionQ40436297
PUMA suppresses intestinal tumorigenesis in miceQ40620684
Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alphaQ40690745
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomesQ41838852
P433issue44
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
apoptotic processQ14599311
P304page(s)37296-37308
P577publication date2012-09-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleToll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis
P478volume287