Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β.

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Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.384743
P932PMC publication ID3481331
P698PubMed publication ID22955269
P5875ResearchGate publication ID230810680

P50authorLivia PuljakQ56958166
Ishtiaq QadriQ57334488
P2093author name stringFrancis R Simon
Jerome Schaack
Mieko Iwahashi
Trina A Knotts
Gordan Kilic
J Gregory Fitz
Jacob E Friedman
Rachel C Janssen
Mahua Choudhury
Shaikh Mizanoor Rahman
P2860cites workHepatitis C virus hijacks host lipid metabolismQ24652319
Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1Q27471632
The NS5A Protein of Bovine Viral Diarrhea Virus Contains an Essential Zinc-Binding Site Similar to That of the Hepatitis C Virus NS5A ProteinQ27477462
Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3Q27477554
Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT PathwayQ27488294
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosisQ27489896
Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic MiceQ27490446
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1Q28216275
Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomesQ28240881
Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-CQ28252951
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in miceQ28507512
Insulin signallingQ28611467
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1Q29615692
Cellular mechanisms of insulin resistanceQ29619549
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interactionQ29619822
Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathwayQ30395512
Molecular mechanism of hepatitis C virus-induced glucose metabolic disordersQ30395601
The interaction of metabolic factors with HCV infection: does it matter?Q30412494
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.Q33721192
Cell and molecular biology of the assembly and secretion of apolipoprotein B-containing lipoproteins by the liverQ33728993
Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitizationQ33812148
Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db miceQ33930211
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) miceQ33943164
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acidsQ34989773
Global epidemiology and burden of hepatitis C.Q35017766
Novel concepts in insulin regulation of hepatic gluconeogenesisQ35213690
Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signallingQ35762318
CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in miceQ36298428
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistanceQ36484059
Coordination of inflammation and metabolism by PPAR and LXR nuclear receptorsQ37265280
Hepatitis C virus: viral proteins on the moveQ37597350
Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathwayQ39744120
Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgammaQ39820957
HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgammaQ40164873
Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratioQ40442238
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virusQ40588817
Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanismQ40806812
CREB (cAMP response element binding protein) and C/EBPalpha (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase gene transcription by adenoviral E1a and cAMP.Q40841380
Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expressionQ41550238
Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cellsQ42153597
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistanceQ42457824
Hepatitis C virus core protein induces hepatic steatosis in transgenic miceQ42983905
Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infectionQ42997461
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcoholQ44116657
Contribution of obesity to hepatitis C-related fibrosis progressionQ44162459
Association between hepatitis C, diabetes mellitus, and race. a case-control studyQ44406442
Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetesQ44675026
Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity statusQ44677821
Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulationQ44856913
Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected].Q45699015
Surrogate alcohols and their metabolites modify histone H3 acetylation: involvement of histone acetyl transferase and histone deacetylaseQ46705645
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liverQ48386175
Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).Q54663541
The Transcription Factor CCAAT/Enhancer-binding Protein β Regulates Gluconeogenesis and Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription during DiabetesQ57272889
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitisQ80229577
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectsteatosisQ1365091
Hepatitis C virusQ708693
P1104number of pages12
P304page(s)37340-37351
P577publication date2012-09-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleIncreased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β
P478volume287

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cites work (P2860)
Q37713887Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus
Q35731525HCV NS5A Up-Regulates COX-2 Expression via IL-8-Mediated Activation of the ERK/JNK MAPK Pathway
Q41682315Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways
Q36978634Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells
Q37682496Immunologic, metabolic and genetic factors in hepatitis C virus infection
Q64080308Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review
Q26752335PGC-1α, glucose metabolism and type 2 diabetes mellitus
Q34907844Transcriptome analysis of duck liver and identification of differentially expressed transcripts in response to duck hepatitis A virus genotype C infection

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