New insights into the biology of osteocalcin

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New insights into the biology of osteocalcin is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.BONE.2015.05.046
P932PMC publication ID4670816
P698PubMed publication ID26055108
P5875ResearchGate publication ID278047345

P2093author name stringRyan C Riddle
Thomas L Clemens
Meredith L Zoch
P2860cites workThe osteoblast: an insulin target cell controlling glucose homeostasis.Q54601524
Undercarboxylated osteocalcin, muscle strength and indices of bone health in older womenQ57086305
The effect of Gla-containing proteins on the precipitation of insoluble saltsQ57227451
Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolismQ58326841
Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcinQ61760408
Vitamin K-dependent carboxylase: utilization of decarboxylated bone Gla protein and matrix Gla protein as substrates.Q64994021
Evidence for the formation of a complex between osteopontin and osteocalcinQ67586025
Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone proteinQ69875680
Matrix Gla protein, a new gamma-carboxyglutamic acid-containing protein which is associated with the organic matrix of boneQ71002237
Calcium-dependent alpha-helical structure in osteocalcinQ71608869
Sex steroids and boneQ74124341
Evidence that the mouse osteocalcin-related gene does not encode nephrocalcinQ80093937
Relation between serum osteocalcin levels and body composition in obese childrenQ86797224
Endocrine regulation of energy metabolism by the skeletonQ22337453
Identification of a novel extracellular cation-sensing G-protein-coupled receptorQ24548217
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionQ24629773
Bone recognition mechanism of porcine osteocalcin from crystal structureQ27642452
The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjectsQ28263140
Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrateQ28271279
Chromosomal localization of the human osteocalcin geneQ28279554
The molecular basis of blood coagulationQ28294854
Regulation of male fertility by the bone-derived hormone osteocalcinQ28300656
Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish menQ28303182
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA proteinQ28304798
GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivoQ28307776
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massQ28505908
Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblastsQ28591040
Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in boneQ28646319
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.Q30300318
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axisQ30418935
GPRC6A null mice exhibit osteopenia, feminization and metabolic syndromeQ30440683
Maternal and offspring pools of osteocalcin influence brain development and functionsQ30559531
A prospective study of changes in bone turnover and bone density associated with regaining weight in women with anorexia nervosaQ33219841
Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebratesQ33341094
Association analysis of genetic polymorphisms and potential interaction of the osteocalcin (BGP) and ER-alpha genes with body mass index (BMI) in premenopausal Chinese womenQ33557227
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in miceQ33559637
Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasisQ33602544
Total osteocalcin in serum predicts testosterone level in male type 2 diabetes mellitusQ33756367
Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formationQ33767756
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolismQ34021680
Leptin regulates bone formation via the sympathetic nervous systemQ34157988
Effect of phylloquinone supplementation on glucose homeostasis in humansQ34308143
The vitamin K cycle.Q34443182
Dilatational band formation in boneQ34468075
Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in miceQ34600479
Endocrine regulation of male fertility by the skeletonQ34642934
Effects of physiological variations in circulating insulin levels on bone turnover in humans.Q34894438
Characterization of a gamma-carboxyglutamic acid-containing protein from boneQ35000322
Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen productionQ35005578
Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine boneQ35029272
Impaired osteoblast function in GPRC6A null miceQ35156186
GGCX and VKORC1 inhibit osteocalcin endocrine functions.Q35184466
Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in miceQ35235417
Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study).Q35597885
Significant association between body composition phenotypes and the osteocalcin genomic region in normative human populationQ35668413
FoxOs at the crossroads of cellular metabolism, differentiation, and transformationQ35770614
T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblastsQ35806647
Relationship of testosterone and osteocalcin levels during growthQ35832494
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasisQ35841927
Circulating osteocalcin level is not associated with incident type 2 diabetes in middle-aged male subjects: mean 8.4-year retrospective follow-up studyQ36181331
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.Q36315662
Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteinsQ36322457
Excessive mineralization with growth plate closure in rats on chronic warfarin treatmentQ36326661
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type miceQ36516140
The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males.Q51316512
The association of osteocalcin and adiponectin with glucose metabolism in nondiabetic postmenopausal women.Q51322093
Reduced serum total osteocalcin is associated with central obesity in Korean children.Q51322204
The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men.Q54349941
Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitusQ36591476
Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptorsQ36644953
The search for type 2 diabetes susceptibility loci: the chromosome 1q storyQ36787574
Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolismQ36850959
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.Q36920314
Associations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and β-cell function in overweight adultsQ36982011
Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanismQ37075911
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stressQ37105304
The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblastsQ37328439
Serum osteocalcin is significantly related to indices of obesity and lipid profile in Malaysian menQ37488676
NMR investigation of the role of osteocalcin and osteopontin at the organic-inorganic interface in boneQ37513381
Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6aQ37597067
Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytesQ37698314
Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug developmentQ37745635
The contribution of bone to whole-organism physiologyQ37977006
The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological functionQ38137171
The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.Q38199459
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.Q38312132
WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.Q39159584
Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-κB signaling pathwayQ39194993
Baseline osteocalcin levels and incident diabetes in a 3-year prospective study of high-risk individualsQ39250248
Cloning and characterization of a family C orphan G-protein coupled receptorQ40437548
The osteocalcin propeptide is not secreted in vivo or in vitroQ41114125
Increased bone formation in osteocalcin-deficient mice.Q41182577
Effect of Ca2+ on the structure of vitamin K-dependent coagulation factorsQ41199018
Short stature in anorexia nervosa patientsQ41505541
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African AmericansQ42124640
Decreased sensory responses in osteocalcin null mutant mice imply neuropeptide functionQ42637115
Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levelsQ43054615
Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials.Q43461322
A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight lossQ43741405
Osteocalcin is inversely associated with glucose levels in middle-aged Tibetan men with different degrees of glucose toleranceQ44939757
Cloning of hOST-PTP: the only example of a protein-tyrosine-phosphatase the function of which has been lost between rodent and human.Q45052360
Undercarboxylated osteocalcin is positively associated with free testosterone in male patients with type 2 diabetes mellitusQ45332136
Relationships between serum osteocalcin levels versus blood glucose, insulin resistance and markers of systemic inflammation in central Indian type 2 diabetic patients.Q45925794
Isolation and sequence of the vitamin K-dependent matrix Gla protein from the calcified cartilage of the soupfin sharkQ46295497
Osteocalcin is higher across pregnancy in Caucasian women with gestational diabetes mellitusQ47592507
Studies of osteocalcin function in dentin formation in rodent teethQ47810007
γ-Glutamyl carboxylase in osteoblasts regulates glucose metabolism in mice.Q50631819
Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.Q50678899
Association between serum osteocalcin and insulin resistance in postmenopausal, but not premenopausal, women in Korea.Q51028724
Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion.Q51315728
P921main subjectosteocalcinQ59250722
P304page(s)42-49
P577publication date2015-06-06
P1433published inBoneQ15755003
P1476titleNew insights into the biology of osteocalcin
P478volume82

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cites work (P2860)
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