Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

scientific article

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.3912
P932PMC publication ID4673252
P698PubMed publication ID26035354
P5875ResearchGate publication ID277599474

P2093author name stringYing Yan
Surinder K Batra
Apar K Ganti
Maneesh Jain
Suprit Gupta
Satyanarayana Rachagani
Chittibabu Guda
Moorthy P Ponnusamy
Dhanya Haridas
Parthasarathy Seshacharyulu
Imayavaramban Lakshmanan
Suhasini Joshi
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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcQ24614033
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MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cellsQ24630950
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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceQ29617045
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Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinomaQ30430971
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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependencyQ33963261
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ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinomaQ34582105
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MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cellsQ35035434
Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cellsQ36206219
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.Q36437150
Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cellsQ36610877
Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family membersQ36643816
HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.Q36957145
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Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.Q37523202
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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyQ39960692
MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins.Q40150208
Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance.Q40671576
HER3 overexpression and survival in solid tumors: a meta-analysisQ43659959
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growthQ44120544
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinomaQ44645468
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Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progressionQ46119162
HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissuesQ47612892
Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinomaQ48704352
HER3 overexpression as an independent indicator of poor prognosis for patients with curatively resected pancreatic cancer.Q53142393
Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasmsQ71048246
MUC4 expression increases progressively in pancreatic intraepithelial neoplasiaQ74385664
Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinomaQ81341144
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)21085-21099
P577publication date2015-05-16
P1433published inOncotargetQ1573155
P1476titleNovel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
P478volume6

Reverse relations

cites work (P2860)
Q64951879Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells.
Q33884794Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis
Q41859754Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer
Q37706759Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas
Q26739942Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)
Q37174016Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation
Q37164549MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer
Q38688917MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma.
Q38804960MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling.
Q39410445Mucins in pancreatic cancer: biological role, implications in carcinogenesis and applications in diagnosis and therapy
Q37705843NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling
Q36917818PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.
Q58803127Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
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Q64067178Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

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