Bad can act as a key regulator of T cell apoptosis and T cell development.

scientific article

Bad can act as a key regulator of T cell apoptosis and T cell development. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.189.3.575
P932PMC publication ID2192908
P698PubMed publication ID9927519
P5875ResearchGate publication ID236244761

P50authorHugh BradyQ58949320
P2093author name stringM Coles
O Williams
S Taga
D Kioussis
G Gil-Gómez
M Tolaini
T Norton
C L Mok
P2860cites workDimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteinsQ24310631
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell deathQ24311298
Bcl-2 targets the protein kinase Raf-1 to mitochondriaQ24321753
The structure of the human CD2 gene and its expression in transgenic miceQ24563712
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activityQ28249553
Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11Q28254663
Interleukin-3-induced phosphorylation of BAD through the protein kinase AktQ28255373
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)Q28297419
Apoptosis by death factorQ28304002
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosisQ28588677
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometryQ29617253
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cellsQ30411850
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.Q34300766
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.Q34422208
Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgeneQ35045775
T-cell receptor-specific monoclonal antibodies against a V beta 11-positive mouse T-cell cloneQ35113460
Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.Q35764153
The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entryQ35917268
Bax alpha perturbs T cell development and affects cell cycle entry of T cellsQ35917304
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinaseQ36103541
Apoptosis and programmed cell death in immunityQ36135180
The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymusQ36362663
Positive selection is not required for thymic maturation of transgenic gamma delta T cellsQ36366715
The action of Bax and bcl-2 on T cell selectionQ36401807
Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic miceQ37319686
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.Q37355656
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.Q40024055
Regulation of lymphocyte survival by the bcl-2 gene familyQ40444925
Positive selection of lymphocytesQ40807424
Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.Q41062034
T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.Q41064142
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycinQ41412030
The proto-oncogene Bcl-2 and its role in regulating apoptosisQ41492030
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapyQ41659044
Mechanism of activation and function of protein kinase B.Q41732739
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytesQ44192187
Bcl-2-family proteins: the role of the BH3 domain in apoptosisQ47686942
The developmental fate of T cells is critically influenced by TCRgammadelta expression.Q51097761
Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14-3-3 Isoforms and P11Q55868670
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient miceQ57222709
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorshipQ57338704
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivoQ59082223
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
A Bad kinase makes goodQ59099312
Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic miceQ69368112
Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosisQ71687705
Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic miceQ72037334
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factorQ72121269
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2FQ73925270
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)575-586
P577publication date1999-02-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleBad can act as a key regulator of T cell apoptosis and T cell development
P478volume189