The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.

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The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.193.8.967
P932PMC publication ID2193406
P698PubMed publication ID11304557
P5875ResearchGate publication ID273559414

P50authorBurkhard BecherQ48129628
P2093author name stringB G Durell
R J Noelle
W F Hickey
A V Miga
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cellsQ28187669
Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, miceQ28506176
Brain-immune connection: immuno-regulatory properties of CNS-resident cellsQ33826555
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosisQ33835268
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivoQ34049368
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cellsQ34289467
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosisQ37696199
Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitroQ39771445
Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimerasQ41625499
The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cellsQ41739600
In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitisQ48233123
CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.Q48286228
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitisQ48913563
Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microgliaQ48926167
Regulation of CD14 expression on human adult central nervous system-derived microgliaQ48942299
Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune transferred experimental autoimmune encephalomyelitis: An investigation using rat radiation bone marrow chimerasQ61709781
Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40Q72093299
Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells comparedQ72169034
CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNSQ73336410
Suppression of murine thyroiditis via blockade of the CD40-CD40L interactionQ73347843
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic miceQ73900356
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administrationQ74303612
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
inflammationQ101991
experimental autoimmune encephalomyelitisQ494066
P304page(s)967-974
P577publication date2001-04-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleThe clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
P478volume193