Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma

scientific article

Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma is …
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scholarly articleQ13442814

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P356DOI10.1016/J.ORALONCOLOGY.2014.09.013
P932PMC publication ID4678773
P698PubMed publication ID25311433

P50authorBevan YuehQ42208740
P2093author name stringAshok Saluja
Veena Sangwan
Rui Lin
Caitlin Fujisawa
Emiro Caicedo-Granados
P2860cites workHuman Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United StatesQ22306233
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Epidemiologic classification of human papillomavirus types associated with cervical cancerQ29616213
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Q33209208
Human papillomavirus immortalization and transformation functionsQ33962694
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitorsQ34379259
Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosisQ34565515
Small molecule inhibitors of human papillomavirus protein - protein interactionsQ35107717
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.Q36710840
Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)Q36717554
A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancerQ36851289
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteinsQ37419555
Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinomaQ37549460
Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrestQ39191981
Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivoQ39821586
E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cellsQ39874615
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.Q40073570
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cellsQ40410781
Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis.Q40447456
Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamstersQ42820344
Prevalence of oral HPV infection in the United States, 2009-2010.Q43794722
China approves first gene therapyQ44580430
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivoQ46054917
Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordiiQ50135757
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1149-1156
P577publication date2014-10-11
P1433published inOral OncologyQ7099367
P1476titleWild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma
P478volume50

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cites work (P2860)
Q38818544A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies.
Q40135846Analysis of the current status of research on human papillomavirus-associated head and neck cancers based on recent Chinese literature
Q90405381Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model
Q54256882High NOTCH1 mRNA Expression Is Associated with Better Survival in HNSCC.
Q38999029Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation ± Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis
Q52859512Novel p53 therapies for head and neck cancer.
Q34502672Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts
Q64106301RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression
Q26782255Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer