Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

scientific article

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..11215172Y
P356DOI10.1073/PNAS.1422015112
P932PMC publication ID4679044
P698PubMed publication ID26598706

P50authorAdrian HarrisQ37374768
P2093author name stringFrancesca M Buffa
Chunxu Qu
Jun Yang
Jiannis Ragoussis
Dilair Baban
Andrew M Davidoff
Rodrigo B Interiano
Ji-Liang Li
Esther Bridges
Robert Nicholson
Dylan T Jones
Alaa AlTahan
Nathan Vogt
P2860cites workActivation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Comprehensive molecular portraits of human breast tumoursQ24630844
Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor relatedQ24806403
Activating ESR1 mutations in hormone-resistant metastatic breast cancerQ27852630
ESR1 ligand-binding domain mutations in hormone-resistant breast cancerQ27852637
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesisQ28200184
Connections and regulation of the human estrogen receptorQ28201958
Open source clustering softwareQ29547702
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationsQ29614275
Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263Q31814776
Cellular and molecular pharmacology of antiestrogen action and resistanceQ31921111
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patientsQ33519584
A CTCF-independent role for cohesin in tissue-specific transcriptionQ33812535
Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancerQ33845160
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Overexpression of POLQ confers a poor prognosis in early breast cancer patientsQ34051213
Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patientsQ34141028
FOXA1 is a key determinant of estrogen receptor function and endocrine responseQ34508204
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growthQ34664804
The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcriptionQ35143427
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.Q36029877
Estrogen receptor target gene: an evolving conceptQ36362136
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxiaQ37145375
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alphaQ37158836
Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and betaQ37268581
Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancerQ37472659
Biological determinants of endocrine resistance in breast cancerQ37585095
Role of hypoxia-inducible factors in epigenetic regulation via histone demethylasesQ37618868
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancerQ40020433
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.Q40101179
Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonistsQ40714917
Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancerQ40952791
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic gradeQ42510471
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metageneQ42739835
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.Q43154570
Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxiaQ43270175
Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.Q43913511
Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast CancerQ58211875
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancerQ59289357
Hypoxia-inducible factor 1: master regulator of O2 homeostasisQ77485489
Hypoxia and estrogen co-operate to regulate gene expression in T-47D human breast cancer cellsQ80256412
P433issue49
P407language of work or nameEnglishQ1860
P304page(s)15172-15177
P577publication date2015-11-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEstrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer
P478volume112

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cites work (P2860)
Q55119106BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.
Q58210984Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
Q57109688Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT
Q47836759Deciphering metabolic rewiring in breast cancer subtypes
Q64255931Deciphering the Molecular Mechanisms Sustaining the Estrogenic Activity of the Two Major Dietary Compounds Zearalenone and Apigenin in ER-Positive Breast Cancer Cell Lines
Q91277769Disinfection Byproducts Bind Human Estrogen Receptor-α
Q64974925Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Q46727445Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue
Q37327681Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells
Q92281756Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences
Q64236018HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice
Q36998209HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.
Q48225818Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.
Q64968674Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
Q37662078Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells
Q59812894Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HIF-1α/CXCR4 pathway
Q89237242Identification of epigenetic modulators in human breast cancer by integrated analysis of DNA methylation and RNA-Seq data
Q64245167Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
Q38755956MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha
Q64922459Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression.
Q26749333Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction
Q99594542Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
Q59810728Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium
Q92643741The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer
Q92479149The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
Q98185640Tumorigenesis and Progression As A Consequence of Hypoxic TME:A Prospective View upon Breast Cancer Therapeutic Targets
Q96131917USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer
Q90697973miR-939-3p promotes epithelial-mesenchymal transition and may be used as a prognostic marker in hepatocellular carcinoma

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