Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

journal article published in 2012

Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016839407
P356DOI10.1186/1743-8977-9-35
P2880NIOSHTIC-2 ID20062673
P932PMC publication ID3489700
P698PubMed publication ID22931549
P5875ResearchGate publication ID230761555

P50authorJonathan M SametQ91965319
Patrick N BreysseQ114438535
Alison S. GeyhQ124880073
P2093author name stringJoe G N Garcia
Viswanathan Natarajan
Ting Wang
Lichun Wang
Biji Mathew
Jessica H Siegler
Liliana Moreno-Vinasco
Peter V Usatyuk
Gabriel D Lang
P2860cites workTRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymeraseQ24671634
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangementQ24671831
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinQ24683294
Metal composition of ambient PM2.5 influences severity of allergic airways disease in miceQ24815980
Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha cateninQ28137655
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathwaysQ28394622
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in miceQ28742767
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollutionQ28755724
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1.Q52941644
CD44 Regulates Hepatocyte Growth Factor-mediated Vascular IntegrityQ57372712
The role of microvascular permeability in the pathogenesis of asthmaQ68733990
In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particleQ73827394
The tight junction: morphology to moleculesQ77803392
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repairQ80141901
Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damageQ80491319
Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutantsQ94694112
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart AssociationQ29547381
Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseasesQ29615450
TRP channels as cellular sensorsQ29615917
Oxidative stress induced in pathologies: the role of antioxidantsQ33677999
Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cellsQ33765074
Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.Q33769407
Cytoskeletal regulation of pulmonary vascular permeabilityQ34377340
Targets for pharmacological intervention of endothelial hyperpermeability and barrier functionQ35127984
Reactive oxygen species in pulmonary inflammation by ambient particulatesQ35192350
Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patientsQ35204898
Regulation of tight junctions and loss of barrier function in pathophysiologyQ35756449
Oxygen, reactive oxygen species and tissue damageQ35768599
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathwayQ35995696
TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-riboseQ36160929
Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studiesQ36182324
Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction.Q36808077
Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibitionQ36956158
Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness.Q36992228
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generationQ37101149
Vascular permeability in cardiovascular disease and cancerQ37129687
GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signalingQ37159197
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.Q37247458
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide productionQ37287612
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctionsQ37524262
The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matterQ38459502
Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in miceQ39585593
Complement factor 3 mediates particulate matter-induced airway hyperresponsivenessQ39632141
Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfacesQ39730128
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytesQ39965490
Calpain: new perspectives in molecular diversity and physiological-pathological involvement.Q40694801
Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthaseQ42917158
Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matterQ44689155
Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cellsQ44709135
Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditionsQ46044155
Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activationQ46297565
PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.Q46779729
Calpains: a physiological regulator of the endothelial barrier?Q46866367
Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeabilityQ46874400
P6195funding schemegrantQ230788
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
particulatesQ498957
air pollutionQ131123
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)35
P12526performing organizationJohns Hopkins UniversityQ193727
P577publication date2012-08-29
P1433published inParticle and Fibre ToxicologyQ15724404
P859sponsorNational Institute for Occupational Safety and HealthQ60346
P1476titleParticulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation
P478volume9

Reverse relations

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Q102152267Blood-derived extracellular vesicles isolated from healthy donors exposed to air pollution modulate in vitro endothelial cells behavior
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