IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

scientific article

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2007-06-094615
P932PMC publication ID2200901
P698PubMed publication ID17616639
P5875ResearchGate publication ID6220545

P50authorJeffrey SchlomQ90227155
P2093author name stringClaudia Palena
Tyler J Curiel
Douglas W Grosenbach
Mary T Litzinger
Romaine Fernando
P2860cites workGranulocyte/macrophage-colony stimulating factor produced by recombinant avian poxviruses enriches the regional lymph nodes with antigen-presenting cells and acts as an immunoadjuvantQ73482867
CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progressionQ73867902
Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activityQ78386134
Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancersQ79157496
Phase II trial of denileukin diftitox for relapsed/refractory T-cell non-Hodgkin lymphomaQ79594581
Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitroQ79812085
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cellsQ34147162
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.Q34504134
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunityQ34505678
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.Q34515741
Increase of regulatory T cells in the peripheral blood of cancer patients.Q34531138
Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanomaQ34943798
The peripheral generation of CD4+ CD25+ regulatory T cellsQ35154721
Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine virusesQ35234767
Control of immune homeostasis by naturally arising regulatory CD4+ T cellsQ35589845
T-cell priming in bone marrow: the potential for long-lasting protective anti-tumor immunityQ35601732
Denileukin diftitox: a concise clinical reviewQ36066136
The bone marrow: a nest for migratory memory T cells.Q36174862
Regulatory T cells in ovarian cancer: biology and therapeutic potentialQ36321305
Gene expression and cytopathic effect of vaccinia virus inactivated by psoralen and long-wave UV lightQ39873004
Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cellsQ40252921
IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic miceQ40265574
The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumorsQ40408782
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.Q40614121
Mice transgenic for human carcinoembryonic antigen as a model for immunotherapyQ41051977
Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity.Q43958945
Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamideQ45182740
Cellular and humoral immunity against vaccinia virus infection of miceQ45642985
Antitumor Activity and Immune Responses Induced by a Recombinant Carcinoembryonic Antigen-Vaccinia Virus VaccineQ45865346
CD25 expression is correlated with histological grade and response to denileukin diftitox in cutaneous T-cell lymphomaQ46893226
Confirmation of the activity of the interleukin-2 fusion toxin denileukin diftitox against chemorefractory chronic lymphocytic leukemia, including cases with chromosome 17p deletions and without detectable CD25 expressionQ47433363
Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2.Q53961036
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.Q54692947
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinomaQ56904280
CD4+CD25high regulatory cells in human peripheral bloodQ56905059
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsQ58234949
Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based VaccinesQ58326930
Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effectsQ59489950
Interleukin 2 (IL-2) receptor expression and sensitivity to diphteria fusion toxin DAB389IL-2 in cultured hematopoietic cellsQ71129142
A triad of costimulatory molecules synergize to amplify T-cell activationQ73229810
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
P304page(s)3192-3201
P577publication date2007-07-06
P1433published inBloodQ885070
P1476titleIL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
P478volume110

Reverse relations

cites work (P2860)
Q35157591A novel oxygen carrier "YQ23" suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells.
Q37118188A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting
Q38171325Adoptive immunotherapy of metastatic breast cancer: present and future
Q36988746Advancements in immune tolerance
Q38029122Advances in targeted therapeutic agents
Q35122843An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma
Q37276644Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.
Q48480477Anti-GITR therapy promotes immunity against malignant glioma in a murine model.
Q35630407B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Q40101895Bacterial Toxins for Cancer Therapy
Q38741294Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment
Q37437275Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma
Q89724967CCL22 Signaling in the Tumor Environment
Q35015717CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
Q37908998Cancer immunotherapy--revisited
Q36866158Cancer vaccines: Looking to the future
Q36368968Cancer vaccines: current directions and perspectives in prostate cancer
Q26745444Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy
Q37132892Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation
Q35919850Chitosan as an adjuvant for a Helicobacter pylori therapeutic vaccine
Q85062314Circulating regulatory T cells (CD4+CD25+FOXP3+) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide
Q37179415Combating immunosuppression in glioma
Q36828834Construction and Production of Foxp3-Fc (IgG) DNA Vaccine/Fusion Protein
Q36317185Current perspectives in prostate cancer vaccines
Q49997332DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice
Q45898692DAB389IL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells.
Q36755513Delicate balance among three types of T cells in concurrent regulation of tumor immunity
Q64268077Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
Q44933756Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.
Q39756932Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma
Q37412327Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
Q36787548Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.
Q39093557Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells
Q64988693Differential Regulation of T-cell mediated anti-tumor memory and cross-protection against the same tumor in lungs versus skin.
Q36016369Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates
Q36043797Distinct effects of saracatinib on memory CD8+ T cell differentiation
Q49834009E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma: A phase 1 study.
Q26774934Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications
Q38809772Emerging Opportunities and Challenges in Cancer Immunotherapy.
Q39789605Engineered interleukin-2 antagonists for the inhibition of regulatory T cells
Q37620568Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers
Q43199366Forkhead box P3-positive regulatory T cells in immune surveillance and cancer
Q36915916FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
Q37287162How tumours escape mass destruction
Q38669273Immune Therapy
Q37873928Immune therapy for ovarian cancer: promise and pitfalls
Q33878721Immunogenic and tolerogenic effects of the chimeric IL-2-diphtheria toxin cytocidal agent Ontak(®) on CD25(+) cells
Q37123810Immunoregulatory T cells: role and potential as a target in malignancy
Q35603131Immunosuppressive tumor microenvironment in cervical cancer patients
Q37829504Immunotherapeutic modulation of the suppressive liver and tumor microenvironments
Q41878129Immunotherapy as a strategy for the treatment of non-small-cell lung cancer
Q38390104Immunotherapy prospects in the treatment of lung cancer and mesothelioma
Q38000768Immunotherapy: a useful strategy to help combat multidrug resistance
Q35669197In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
Q37469869Inhibition of TGF-β1 signaling promotes central memory T cell differentiation
Q33629475Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
Q38069640Ipilimumab in prostate cancer
Q48214652Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy.
Q39196680Maternal T Regulatory Cell Depletion Impairs Embryo Implantation Which Can Be Corrected With Adoptive T Regulatory Cell Transfer
Q30513468Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.
Q37137430New Approaches to Immunotherapy for HPV Associated Cancers
Q36938731New insights into the role of the immune microenvironment in breast carcinoma.
Q26770391Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic)
Q39472057Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice
Q38985262Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells
Q26997338Optimal management of metastatic melanoma: current strategies and future directions
Q37236406Optimizing denileukin diftitox (Ontak) therapy
Q37259568PR1 vaccination in myeloid malignancies
Q34023724Pattern response of dendritic cells in the tumor microenvironment and breast cancer
Q37340462Peptide-based vaccines for cancer: realizing their potential
Q34099760Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma
Q37071100Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection
Q33927418Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance
Q60938672Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases
Q37259642Promising particle-based vaccines in cancer therapy.
Q38089935Prostate cancer vaccines.
Q36273796Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products
Q34238776Recombinant adenovirus IL-24-Bax promotes apoptosis of hepatocellular carcinoma cells in vitro and in vivo
Q37031308Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis
Q37174953Regulatory T cells and treatment of cancer
Q91297827Regulatory T cells in cancer immunosuppression - implications for anticancer therapy
Q54329903Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression.
Q48265824Regulatory effects of dexamethasone on NK and T cell immunity.
Q37251467Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells
Q40070517Suppressor Cell-Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis
Q37800935T regulatory cells in cancer: recent advances and therapeutic potential
Q34076526TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells
Q43280097Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis
Q38005176Targeting NKG2D in tumor surveillance
Q37595721Targeting Treg cells in situ: emerging expansion strategies for (CD4(+)CD25(+)) regulatory T cells
Q37952796Targeting the tumor microenvironment by immunotherapy: part 2.
Q33631986The role of regulatory T cells in cancer
Q27006663The role of regulatory T cells in cancer immunology
Q35894347Therapeutic cancer vaccines: current status and moving forward
Q28476803Therapeutic enhancement of protective immunity during experimental leishmaniasis
Q34527281Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer
Q37270929Therapeutic vaccines for non-Hodgkin B-cell lymphoma.
Q37474385Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation
Q37724053Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy
Q64108546Turning the Tide Against Regulatory T Cells
Q34075574Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells
Q82980799Upfront denileukin diftitox as in vivo regulatory T-cell depletion in order to enhance vaccination effects in a canine allogeneic hematopoietic stem cell transplantation model
Q33734281Vaccines against human carcinomas: strategies to improve antitumor immune responses

Search more.