Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway

scientific article

Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-05-1654
P698PubMed publication ID16467077

P2093author name stringJoell J Gills
Phillip A Dennis
Regan M Memmott
Courtney A Granville
P433issue3 Pt 1
P407language of work or nameEnglishQ1860
P921main subjectdisabilityQ12131
sirolimusQ32089
P304page(s)679-689
P577publication date2006-02-01
P1433published inClinical Cancer ResearchQ332253
P1476titleHandicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
P478volume12

Reverse relations

cites work (P2860)
Q33707181A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation
Q36482989A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases.
Q36755458Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors
Q40164038Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
Q34872991Anaphylactic shock depends on PI3K and eNOS-derived NO.
Q35205410Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches.
Q24307014B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
Q28397537Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities
Q37109227Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Q45938898Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice.
Q33354798Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
Q28572913Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin
Q38112122Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer
Q42197476Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma
Q36651450Effect of pioglitazone on the abrogated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart
Q36821373Emerging therapies for colorectal cancer
Q36097144Emerging therapies in pancreas cancer
Q35095146Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells
Q36784736Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells
Q33694487Extracellular matrix molecules: potential targets in pharmacotherapy.
Q36901468Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth
Q37045209Genetic mutations involved in melanoma: a summary of our current understanding
Q34345248Genetic variations in a PTEN/AKT/mTOR axis and prostate cancer risk in a Chinese population
Q42758534Glucose transporter-1 as a new therapeutic target in laryngeal carcinoma
Q35437204High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs
Q33266468High precision multi-genome scale reannotation of enzyme function by EFICAz
Q34995642Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules
Q36807494Inhibition of Akt pathways in the treatment of prostate cancer
Q45408203Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells
Q36568861Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.
Q35052439Integrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infection
Q40043123Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Q93082677MALAT1 promotes gastric adenocarcinoma through the MALAT1/miR-181a-5p/AKT3 axis
Q37211362Malignant melanoma in the 21st century: the emerging molecular landscape
Q30432032Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
Q39132772Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.
Q36634023Molecular markers of prognosis and novel therapeutic strategies for urothelial cell carcinomas
Q36086507PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma
Q28383083PI3K/PTEN signaling in angiogenesis and tumorigenesis
Q35606261Phosphatidylinositol-3-kinase as a therapeutic target in melanoma
Q36461618Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
Q46956224Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
Q39882765Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
Q29614734Ras, PI(3)K and mTOR signalling controls tumour cell growth
Q33424649Results of a phase 1 trial combining ridaforolimus and MK-0752 in patients with advanced solid tumours
Q34261684Retracted: SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
Q36844334Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
Q42868139Roles and controls of mTOR in the heart. Focus on "mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy".
Q39637442Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors
Q38098888Targeting MAPK pathway in melanoma therapy
Q37317000Targeting important pathways in head and neck cancer: from the bench to the clinic
Q36804407Targeting the PI3K and MAPK pathways to treat Kaposi's-sarcoma-associated herpes virus infection and pathogenesis
Q37135372The ERBB3 receptor in cancer and cancer gene therapy
Q39951694The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
Q37244719The biology and management of uveal melanoma
Q36561728The mTOR pathway in breast cancer
Q37894106The mTOR protein as a target in thyroid cancer.
Q37290512The molecular genetics of breast cancer and targeted therapy
Q46666883The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
Q38983353The novel PI3 kinase inhibitor, BAY 80-6946, impairs melanoma growth in vivo and in vitro
Q37310991Translational up-regulation of Aurora-A in EGFR-overexpressed cancer
Q36791090YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression
Q37210960[18F]fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy.
Q37317165mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trials
Q43236080mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis

Search more.