Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel

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Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1085/JGP.115.3.287
P932PMC publication ID2217204
P698PubMed publication ID10694258
P5875ResearchGate publication ID12621863

P2093author name stringD Kim
A Pleumsamran
P2860cites workExternal blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acidsQ24564480
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2Q28340648
Arachidonic acid activation of a new family of K+ channels in cultured rat neuronal cellsQ28367882
A mechanosensitive K+ channel in heart cells. Activation by arachidonic acidQ28758670
Fatty acid transport: difficult or easy?Q32067353
Fatty acids inhibit apical membrane chloride channels in airway epitheliaQ33807711
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed eventsQ34016948
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimersQ34137507
Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sitesQ34179830
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.Q34391682
Membrane phospholipid control of nucleotide sensitivity of KATP channelsQ34478704
Fatty acid homeostasis in the normoxic and ischemic heartQ35531455
Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphatesQ35806004
Fatty acids suppress voltage-gated Na+ currents in HEK293t cells transfected with the alpha-subunit of the human cardiac Na+ channelQ35935540
Effector contributions to G beta gamma-mediated signaling as revealed by muscarinic potassium channel gatingQ36417623
Arachidonic acid metabolites alter G protein-mediated signal transduction in heart. Effects on muscarinic K+ channelsQ36434652
Cytosolic protein concentration is the primary volume signal for swelling-induced [K-Cl] cotransport in dog red cellsQ36435045
Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibitionQ36438954
Direct regulation of ion channels by fatty acidsQ36649339
Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acidsQ36858387
Long-chain fatty acids activate calcium channels in ventricular myocytesQ37111241
Structural and functional features of different types of cytoplasmic fatty acid-binding proteinsQ37632328
Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteinsQ37661135
Kir2.1 inward rectifier K+ channels are regulated independently by protein kinases and ATP hydrolysisQ38301665
Modulation of ion channels by arachidonic acidQ40394692
Modulation of K+ channels by arachidonic acid in T84 cells. I. Inhibition of the Ca(2+)-dependent K+ channel.Q41066502
Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms and messengersQ41387798
Stretch activation of a toad smooth muscle K+ channel may be mediated by fatty acidsQ41674501
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectificationQ42282616
PIP2 and PIP as determinants for ATP inhibition of KATP channelsQ42538515
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2.Q42555612
Molecular determinants for sodium-dependent activation of G protein-gated K+ channelsQ42595329
Uncoupling of cardiac muscarinic and beta-adrenergic receptors from ion channels by a guanine nucleotide analogueQ44618242
Acetylcholine activation of K+ channels in cell-free membrane of atrial cellsQ46252836
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channelQ46398883
Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channelQ46902962
Modulation of rat atrial G protein-coupled K+ channel function by phospholipidsQ48221723
A G protein couples serotonin and GABAB receptors to the same channels in hippocampusQ48265711
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactionsQ48906142
Activation of the endothelin receptor inhibits the G protein-coupled inwardly rectifying potassium channel by a phospholipase A2-mediated mechanismQ48921685
ATP-dependent regulation of a G protein-coupled K+ channel (GIRK1/GIRK4) expressed in oocytesQ48967950
Regional distribution and rate of production of free fatty acids in rat brain.Q51124182
Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.Q52568167
GTP-binding proteins couple cardiac muscarinic receptors to a K channel.Q53737873
ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes.Q54508115
Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heartQ59068860
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cellsQ59095481
Modulation of acetylcholine-activated K+ channel function in rat atrial cells by phosphorylationQ68253440
Regulation of K+ channels in cardiac myocytes by free fatty acidsQ68357977
Arachidonic acid inhibits sodium currents and synaptic transmission in cultured striatal neuronsQ70478374
Modulation of the serotonin-activated K+ channel by G protein subunits and nucleotides in rat hippocampal neuronsQ70892228
Regulation of atrial muscarinic K+ channel activity by a cytosolic protein via G protein-independent pathwayQ71463913
P433issue3
P921main subjectfatty acidQ61476
P304page(s)287-304
P577publication date2000-03-01
P1433published inThe Journal of General PhysiologyQ1092259
P1476titleCytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel
P478volume115

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cites work (P2860)
Q57253317A Switch Mechanism for Gβγ Activation of IKACh
Q37191018Arachidonic acid and ion channels: an update
Q28366329Arachidonic acid as a bioactive molecule
Q34307912Coordination of membrane excitability through a GIRK1 signaling complex in the atria
Q34605389Effects of unsaturated fatty acids on calcium-activated potassium current in gastric myocytes of guinea pigs
Q28361626Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site
Q42317096Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge
Q36254295Polyunsaturated Fatty acids in atrial fibrillation: looking for the proper candidates.
Q44478890Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate
Q38972404Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel
Q48886242Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization
Q79665816Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus
Q34342309Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.
Q26827704Sensory TRP channel interactions with endogenous lipids and their biological outcomes
Q34180526Single channel analysis of the regulation of GIRK1/GIRK4 channels by protein phosphorylation.
Q34457658The complex and intriguing lives of PIP2 with ion channels and transporters

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